Metoprolol
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| Pronunciation | /mɛˈtoʊproʊlɑːl/ ⓘ, /mɛtoʊˈproʊlɑːl/ |
| Trade names | Lopressor, others |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a682864 |
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| Routes of administration | By mouth, intravenous |
| Drug class | Beta blocker |
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| Pharmacokinetic data | |
| Bioavailability | 50% (single dose) 70% (repeated administration) |
| Protein binding | 12% |
| Metabolism | Liver via CYP2D6, CYP3A4 |
| Elimination half-life | 3–7 hours |
| Excretion | Kidney |
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| ECHA InfoCard | 100.051.952 |
| Chemical and physical data | |
| Formula | C15H25NO3 |
| Molar mass | 267.369 g·mol−1 |
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| Chirality | Racemic mixture |
| Melting point | 120 °C (248 °F) |
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Metoprolol, sold under the brand name Lopressor among others, is a medication used to treat angina, high blood pressure and a number of conditions involving an abnormally fast heart rate. It is also used to prevent further heart problems after myocardial infarction and to prevent headaches in those with migraines. It is a beta blocker, specifically a selective β1 receptor blocker, and is taken by mouth or is given intravenously.
Common side effects include trouble sleeping, feeling tired, feeling faint, and abdominal discomfort. Large doses may cause serious toxicity. Risk in pregnancy has not been ruled out. It appears to be safe in breastfeeding. The metabolism of metoprolol can vary widely among patients, often as a result of hepatic impairment or CYP2D6 polymorphism.
Metoprolol was first made in 1969, patented in 1970, and approved for medical use in 1978. It is on the World Health Organization's List of Essential Medicines. It is available as a generic medication. In 2022, it was the sixth most commonly prescribed medication in the United States, with more than 65 million prescriptions.