Monoamine oxidase A

MAOA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2Z5Y, 2BXR, 2BXS, 2Z5X
Identifiers
Aliases	MAOA, MAO-A, monoamine oxidase A, BRNRS
External IDs	OMIM: 309850; MGI: 96915; HomoloGene: 203; GeneCards: MAOA; OMA:MAOA - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	43,746,817 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	16,554,057 bp
RNA expression pattern
	Top expressed in
	mucosa of ileum; ; mucosa of colon; ; mucosa of sigmoid colon; ; right lung; ; jejunal mucosa; ; duodenum; ; rectum; ; parotid gland; ; gastric mucosa; ; mucosa of transverse colon;
	Top expressed in
	left colon; ; superior cervical ganglion; ; jejunum; ; duodenum; ; intestinal villus; ; Ileal epithelium; ; stroma of bone marrow; ; endothelial cell of lymphatic vessel; ; crypt of lieberkuhn of small intestine; ; Paneth cell;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	primary amine oxidase activity; oxidoreductase activity;
Cellular component	integral component of membrane; mitochondrial outer membrane; membrane; mitochondrion;
Biological process	catecholamine metabolic process; dopamine catabolic process; neurotransmitter catabolic process; cellular biogenic amine metabolic process; neurotransmitter metabolic process; cytokine-mediated signaling pathway; positive regulation of signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	4128
	17161
	ENSG00000189221
	ENSMUSG00000025037
	P21397
	Q64133
	NM_001270458; NM_000240
	NM_173740
	NP_000231; NP_001257387
	NP_776101
	Wikidata
View/Edit Human	View/Edit Mouse

Monoamine oxidase A, also known as MAO-A, is an enzyme (E.C. 1.4.3.4) that in humans is encoded by the MAOA gene. This gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the oxidative deamination of amines, such as norepinephrine, serotonin and tyramine. A mutation of this gene results in Brunner syndrome. This gene has also been associated with a variety of other psychiatric disorders, including antisocial behavior. Alternatively spliced transcript variants encoding multiple isoforms have been observed.