NFE2L1

NFE2L1
Identifiers
Aliases	NFE2L1, LCR-F1, NRF1, TCF11, nuclear factor, erythroid 2 like 1, NRF-1, NFE2 like bZIP transcription factor 1
External IDs	OMIM: 163260; MGI: 99421; HomoloGene: 20685; GeneCards: NFE2L1; OMA:NFE2L1 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	48,061,545 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	96,720,794 bp
RNA expression pattern
	Top expressed in
	glutes; ; gastrocnemius muscle; ; thoracic diaphragm; ; skeletal muscle tissue; ; tibialis anterior muscle; ; muscle of thigh; ; Skeletal muscle tissue of rectus abdominis; ; Skeletal muscle tissue of biceps brachii; ; Achilles tendon; ; triceps brachii muscle;
	Top expressed in
	muscle of thigh; ; neural layer of retina; ; dentate gyrus of hippocampal formation granule cell; ; lip; ; choroid plexus of fourth ventricle; ; superior frontal gyrus; ; tail of embryo; ; primary visual cortex; ; ankle; ; genital tubercle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA binding; DNA-binding transcription factor activity; transcription coregulator activity; transcription cis-regulatory region binding; DNA-binding transcription activator activity, RNA polymerase II-specific; protein binding; protein domain specific binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; cholesterol binding; protein heterodimerization activity; lipid binding; protein-containing complex binding; DNA-binding transcription factor activity, RNA polymerase II-specific; chromatin binding; promoter-specific chromatin binding;
Cellular component	integral component of membrane; endoplasmic reticulum membrane; membrane; endoplasmic reticulum; nucleus; cytoplasm; cytosol; integral component of endoplasmic reticulum membrane; protein-containing complex;
Biological process	regulation of transcription, DNA-templated; regulation of transcription by RNA polymerase II; anatomical structure morphogenesis; transcription, DNA-templated; positive regulation of transcription, DNA-templated; heme biosynthetic process; erythrocyte differentiation; inflammatory response; positive regulation of transcription by RNA polymerase II; negative regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; cellular response to oxidative stress; positive regulation of transcription from RNA polymerase II promoter in response to stress; cell redox homeostasis; lipid homeostasis; cellular response to cholesterol; negative regulation of transcription from RNA polymerase II promoter in response to stress; regulation of odontoblast differentiation; lipid metabolism; steroid metabolic process; cholesterol metabolic process; cholesterol homeostasis; protein polyubiquitination; fructose 6-phosphate metabolic process; glutathione metabolic process; regulation of mitotic nuclear division; regulation of gene expression; regulation of glucose metabolic process; regulation of lipid metabolic process; regulation of fatty acid metabolic process; cellular homeostasis; spinal cord motor neuron differentiation; glial cell fate commitment; response to endoplasmic reticulum stress; cysteine transport; regulation of inflammatory response; glucose 6-phosphate metabolic process; regulation of proteasomal protein catabolic process; cellular response to cold; regulation of nucleus organization; regulation of response to endoplasmic reticulum stress;
	Sources:Amigo / QuickGO
Orthologs
	4779
	18023
	ENSG00000082641
	ENSMUSG00000038615
	Q14494
	Q61985
	NM_003204; NM_001330261; NM_001330262
NM_001130450; NM_001130451; NM_001130452; NM_001130453; NM_001130454;
	NM_008686; NM_001361682
	NP_001317190; NP_001317191; NP_003195
NP_001123922; NP_001123923; NP_001123924; NP_001123925; NP_001123926;
	NP_032712; NP_001348611
	Wikidata
View/Edit Human	View/Edit Mouse

Nuclear factor erythroid 2-related factor 1 (Nrf1) also known as nuclear factor erythroid-2-like 1 (NFE2L1) is a protein that in humans is encoded by the NFE2L1 gene. Since NFE2L1 is also referred to as Nrf1, it is often confused with nuclear respiratory factor 1.

NFE2L1 is a cap ‘n’ collar, basic-leucine zipper (bZIP) transcription factor. Several isoforms of NFE2L1 have been described for both human and mouse genes. NFE2L1 was first cloned in yeast using a genetic screening method. NFE2L1 is ubiquitously expressed, and high levels of transcript are detected in the heart, kidney, skeletal muscle, fat, and brain. Four separate regions — an asparagine/serine/threonine, acidic domains near the N-terminus, and a serine-rich domain located near the CNC motif — are required for full transactivation function of NFE2L1. NFE2L1 is a key regulator of cellular functions including oxidative stress response, differentiation, inflammatory response, metabolism, cholesterol handling and maintaining proteostasis.