NRF1

NRF1
Identifiers
Aliases	NRF1, ALPHA-PAL, nuclear respiratory factor 1
External IDs	OMIM: 600879; MGI: 1332235; HomoloGene: 3674; GeneCards: NRF1; OMA:NRF1 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	129,757,082 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	30,153,457 bp
RNA expression pattern
	Top expressed in
	cerebellar hemisphere; ; right hemisphere of cerebellum; ; right uterine tube; ; ventricular zone; ; apex of heart; ; anterior pituitary; ; granulocyte; ; ganglionic eminence; ; sural nerve; ; gastrocnemius muscle;
	Top expressed in
	zygote; ; primary oocyte; ; secondary oocyte; ; ventricular zone; ; epiblast; ; Rostral migratory stream; ; Paneth cell; ; granulocyte; ; thymus; ; embryo;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; protein homodimerization activity; DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding; protein binding; core promoter sequence-specific DNA binding; RNA polymerase II core promoter sequence-specific DNA binding; DNA-binding transcription factor activity;
Cellular component	extracellular exosome; nucleoplasm; cytosol; nucleus;
Biological process	regulation of transcription, DNA-templated; regulation of transcription by RNA polymerase II; mitochondrion organization; generation of precursor metabolites and energy; transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	4899
	18181
	ENSG00000106459
	ENSMUSG00000058440
	Q16656
	Q9WU00
	NM_005011; NM_001040110; NM_001293163; NM_001293164
NM_001164226; NM_001164227; NM_001164228; NM_001164229; NM_001164230;
	NM_010938; NM_001361692; NM_001361693; NM_001361694; NM_001361695
	NP_001035199; NP_001280092; NP_001280093; NP_005002
NP_001157698; NP_001157699; NP_001157700; NP_001157701; NP_001157702;
	NP_035068; NP_001348621; NP_001348622; NP_001348623; NP_001348624
	Wikidata
View/Edit Human	View/Edit Mouse

Nuclear respiratory factor 1, also known as Nrf1, Nrf-1, NRF1 and NRF-1, encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternate transcriptional splice variants, which encode the same protein, have been characterized. Additional variants encoding different protein isoforms have been described but they have not been fully characterized. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for "nuclear factor (erythroid-derived 2)-like 1" which has an official symbol of NFE2L1.