NFE2L3

NFE2L3
Identifiers
Aliases	NFE2L3, NRF3, nuclear factor, erythroid 2 like 3, NFE2 like bZIP transcription factor 3
External IDs	OMIM: 604135; MGI: 1339958; HomoloGene: 3168; GeneCards: NFE2L3; OMA:NFE2L3 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	26,187,137 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	51,435,748 bp
RNA expression pattern
	Top expressed in
	gonad; ; placenta; ; body of pancreas; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; epithelium of colon; ; Achilles tendon; ; olfactory zone of nasal mucosa; ; appendix; ; rectum;
	Top expressed in
	transitional epithelium of urinary bladder; ; hair follicle; ; lumbar subsegment of spinal cord; ; superior cervical ganglion; ; corneal stroma; ; lip; ; skin of external ear; ; conjunctival fornix; ; skin of back; ; olfactory epithelium;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA binding; transcription coactivator activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; protein binding; transcription cis-regulatory region binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; nucleus;
Biological process	regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; transcription, DNA-templated;
	Sources:Amigo / QuickGO
Orthologs
	9603
	18025
	ENSG00000050344
	ENSMUSG00000029832
	Q9Y4A8
	Q9WTM4
	NM_004289
	NM_010903
	NP_004280
	NP_035033
	Wikidata
View/Edit Human	View/Edit Mouse

Nuclear factor (erythroid 2)-like factor 3, also known as NFE2L3 or 'NRF3', is a transcription factor that in humans is encoded by the Nfe2l3 gene.

Nrf3 is a basic leucine zipper (bZIP) transcription factor belonging to the Cap ‘n’ Collar (CNC) family of proteins. In 1989, the first CNC transcription factor NFE2L2 was identified. Subsequently, several related proteins were identified, including NFE2L1 and NFE2L3, in different organisms such as humans, mice, and zebrafish. These proteins are specifically encoded in the humans by Nfe2l1 and Nfe2l3 genes respectively.