NOD1

NOD1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2B1W, 2DBD, 2NSN, 2NZ7, 4E9M, 4JQW
Identifiers
Aliases	NOD1, CARD4, CLR7.1, NLRC1, nucleotide binding oligomerization domain containing 1
External IDs	OMIM: 605980; MGI: 1341839; HomoloGene: 4440; GeneCards: NOD1; OMA:NOD1 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	30,478,784 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	54,949,597 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; left ovary; ; right lobe of thyroid gland; ; right ovary; ; gingival epithelium; ; upper lobe of left lung; ; left lobe of thyroid gland; ; apex of heart; ; subcutaneous adipose tissue; ; spleen;
	Top expressed in
	mesenteric lymph nodes; ; granulocyte; ; subcutaneous adipose tissue; ; sciatic nerve; ; right lung; ; spleen; ; cervix; ; myocardium of ventricle; ; islet of Langerhans; ; stroma of bone marrow;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; protein homodimerization activity; protein binding; peptidoglycan binding; identical protein binding; cysteine-type endopeptidase activator activity involved in apoptotic process; CARD domain binding; ATP binding; protein-containing complex binding;
Cellular component	cytoplasm; cytosol; membrane; plasma membrane; basolateral plasma membrane; apical plasma membrane;
Biological process	regulation of apoptotic process; defense response; detection of biotic stimulus; intracellular signal transduction; positive regulation of cell death; immune system process; positive regulation of JNK cascade; positive regulation of xenophagy; positive regulation of NIK/NF-kappaB signaling; cellular response to muramyl dipeptide; JNK cascade; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of dendritic cell antigen processing and presentation; positive regulation of nitric-oxide synthase activity; defense response to bacterium; positive regulation of NF-kappaB transcription factor activity; protein complex oligomerization; detection of bacterium; positive regulation of interleukin-1 beta production; positive regulation of ERK1 and ERK2 cascade; positive regulation of interleukin-6 production; positive regulation of tumor necrosis factor production; positive regulation of I-kappaB kinase/NF-kappaB signaling; inflammatory response; activation of cysteine-type endopeptidase activity involved in apoptotic process; nucleotide-binding oligomerization domain containing signaling pathway; signal transduction; positive regulation of stress-activated MAPK cascade; defense response to Gram-positive bacterium; apoptotic process; innate immune response; interleukin-1-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	10392
	107607
	ENSG00000106100
	ENSMUSG00000038058
	Q9Y239
	Q8BHB0
	NM_006092; NM_001354849
	NM_001171007; NM_172729
	NP_006083; NP_001341778
	NP_001164478; NP_766317
	Wikidata
View/Edit Human	View/Edit Mouse

Nucleotide-binding oligomerization domain-containing protein 1 (NOD1) is a protein receptor that in humans is encoded by the NOD1 gene. It recognizes bacterial molecules and stimulates an immune reaction.

NOD1 protein contains a caspase recruitment domain (CARD). NOD1 is a member of NOD-like receptor protein family and is a close relative of NOD2. NOD1 is an intracellular pattern recognition receptor, which is similar in structure to resistant proteins of plants, and mediates innate and acquired immunity by recognizing molecules containing D-glutamyl-meso-diaminopimelic acid (iE-DAP) moiety, including bacterial peptidoglycan. Nod1 interacts with RIPK2 through the CARDs of both molecules (See the structure of the NOD1 CARD in the right panel). Stimulation of NOD1 by iE-DAP containing molecules results in activation of the transcription factor NF-κB.