Non-POU domain-containing octamer-binding protein

NONO
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3SDE
Identifiers
Aliases	NONO, NMT55, NRB54, P54, P54NRB, PPP1R114, MRXS34, non-POU domain containing, octamer-binding, non-POU domain containing octamer binding
External IDs	OMIM: 300084; MGI: 1855692; HomoloGene: 7212; GeneCards: NONO; OMA:NONO - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	71,301,522 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	100,492,197 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; ventricular zone; ; thymus; ; trachea; ; cerebellar vermis; ; epithelium of bronchus; ; paraflocculus of cerebellum; ; stromal cell of endometrium; ; ovary; ; left ovary;
	Top expressed in
	genital tubercle; ; ventricular zone; ; tail of embryo; ; yolk sac; ; neural layer of retina; ; zygote; ; embryo; ; embryo; ; dentate gyrus of hippocampal formation granule cell; ; lip;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA binding; chromatin binding; transcription cis-regulatory region binding; protein binding; identical protein binding; nucleic acid binding; RNA binding;
Cellular component	paraspeckles; nuclear speck; membrane; nuclear matrix; nucleoplasm; RNA polymerase II transcription regulator complex; nucleolus; nucleus;
Biological process	mRNA splicing, via spliceosome; DNA recombination; regulation of transcription, DNA-templated; rhythmic process; mRNA processing; transcription, DNA-templated; cellular response to DNA damage stimulus; regulation of circadian rhythm; circadian rhythm; RNA splicing; negative regulation of transcription, DNA-templated; negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway; DNA repair; activation of innate immune response; immune system process; innate immune response;
	Sources:Amigo / QuickGO
Orthologs
	4841
	53610
	ENSG00000147140
	ENSMUSG00000031311
	Q15233
	Q99K48
	NM_007363; NM_001145408; NM_001145409; NM_001145410
	NM_001252518; NM_023144
	NP_001138880; NP_001138881; NP_001138882; NP_031389
	NP_001239447; NP_075633
	Wikidata
View/Edit Human	View/Edit Mouse

Non-POU domain-containing octamer-binding protein (NonO) is a protein that in humans is encoded by the NONO gene.

The NonO protein belongs to the Drosophila behaviour/human splicing (DBHS) family of proteins. Proteins in the DHBS family include mammalian SFPQ (splicing factor, proline- and glutamine-rich; a.k.a. PSF), NONO (Non-POU domain-containing octamer-binding protein; a.k.a. p54nrb) and PSPC1 (paraspeckle component 1; a.k.a. PSP1) and invertebrate NONA (Protein no-on-transient A) and Hrp65.