NPAS2

NPAS2
Identifiers
Aliases	NPAS2, MOP4, PASD4, bHLHe9, neuronal PAS domain protein 2
External IDs	OMIM: 603347; MGI: 109232; HomoloGene: 1887; GeneCards: NPAS2; OMA:NPAS2 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	100,996,829 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	39,402,317 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; apex of heart; ; body of stomach; ; left ventricle; ; skin of leg; ; right auricle of heart; ; skin of abdomen; ; prefrontal cortex; ; olfactory zone of nasal mucosa; ; right frontal lobe;
	Top expressed in
	ascending aorta; ; dorsal striatum; ; zygote; ; superior frontal gyrus; ; lumbar subsegment of spinal cord; ; olfactory tubercle; ; secondary oocyte; ; nucleus accumbens; ; aortic valve; ; prefrontal cortex;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	Hsp90 protein binding; protein dimerization activity; DNA-binding transcription factor activity; metal ion binding; protein binding; DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding;
Cellular component	cytoplasm; transcription regulator complex; nucleus; nucleoplasm; cytosol;
Biological process	regulation of transcription, DNA-templated; rhythmic process; positive regulation of DNA repair; negative regulation of cell death; circadian regulation of gene expression; transcription, DNA-templated; cellular response to DNA damage stimulus; response to redox state; positive regulation of transcription, DNA-templated; central nervous system development; circadian rhythm; regulation of response to DNA damage stimulus; positive regulation of transcription by RNA polymerase II; regulation of lipid metabolic process; positive regulation of behavioral fear response;
	Sources:Amigo / QuickGO
Orthologs
	4862
	18143
	ENSG00000170485
	ENSMUSG00000026077
	Q99743
	P97460
	NM_002518
	NM_008719
	NP_002509
	NP_032745
	Wikidata
View/Edit Human	View/Edit Mouse

Neuronal PAS domain protein 2 (NPAS2) also known as member of PAS protein 4 (MOP4) is a transcription factor protein that in humans is encoded by the NPAS2 gene. NPAS2 is paralogous to CLOCK, and both are key proteins involved in the maintenance of circadian rhythms in mammals. In the brain, NPAS2 functions as a generator and maintainer of mammalian circadian rhythms. More specifically, NPAS2 is an activator of transcription and translation of core clock and clock-controlled genes through its role in a negative feedback loop in the suprachiasmatic nucleus (SCN), the brain region responsible for the control of circadian rhythms.