NAD(P)H dehydrogenase (quinone 1)

NQO1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1D4A, 1DXO, 1GG5, 1H66, 1H69, 1KBO, 1KBQ, 1QBG, 2F1O, 3JSX, 4CET, 4CF6, 5EA2, 5EAI, 5A4K
Identifiers
Aliases	NQO1, DHQU, DIA4, DTD, NMOR1, NMORI, QR1, NAD(P)H dehydrogenase, NAD(P)H quinone dehydrogenase 1
External IDs	MGI: 103187; HomoloGene: 695; GeneCards: NQO1; OMA:NQO1 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	69,726,668 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	108,129,838 bp
RNA expression pattern
	Top expressed in
	gallbladder; ; stromal cell of endometrium; ; nasal epithelium; ; olfactory zone of nasal mucosa; ; glomerulus; ; metanephric glomerulus; ; bronchial epithelial cell; ; islet of Langerhans; ; pylorus; ; Epithelium of choroid plexus;
	Top expressed in
	epithelium of stomach; ; pyloric antrum; ; olfactory epithelium; ; mucous cell of stomach; ; transitional epithelium of urinary bladder; ; right kidney; ; duodenum; ; esophagus; ; proximal tubule; ; myocardium of ventricle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	superoxide dismutase activity; cytochrome-b5 reductase activity, acting on NAD(P)H; protein binding; identical protein binding; oxidoreductase activity; NAD(P)H dehydrogenase (quinone) activity; RNA binding; electron transfer activity;
Cellular component	soma; extracellular exosome; cytoplasm; cytosol; dendrite;
Biological process	response to estradiol; negative regulation of catalytic activity; nitric oxide biosynthetic process; regulation of cellular amino acid metabolic process; response to organic cyclic compound; response to nutrient; removal of superoxide radicals; ageing; synaptic transmission, cholinergic; response to oxidative stress; positive regulation of neuron apoptotic process; xenobiotic metabolic process; response to ethanol; response to toxic substance; superoxide metabolic process; negative regulation of apoptotic process; response to electrical stimulus; cellular response to metal ion; electron transport chain; cellular response to hydrogen peroxide; response to nitrogen compound; response to hydrogen sulfide;
	Sources:Amigo / QuickGO
Orthologs
	1728
	18104
	ENSG00000181019
	ENSMUSG00000003849
	P15559
	Q64669
	NM_001286137; NM_000903; NM_001025433; NM_001025434
	NM_008706
	NP_000894; NP_001020604; NP_001020605; NP_001273066
	NP_032732
	Wikidata
View/Edit Human	View/Edit Mouse

NAD(P)H dehydrogenase [quinone] 1 is an enzyme that in humans is encoded by the NQO1 gene. This protein-coding gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a 2-electron reductase (enzyme). This FAD-binding protein forms homodimers and performs two-electron reduction of quinones to hydroquinones and of other redox dyes. It has a preference for short-chain acceptor quinones, such as ubiquinone, benzoquinone, juglone and duroquinone. This gene has an important paralog NQO2. This protein is located in the cytosol.

NQO1 enzyme expression can be induced by dioxin and inhibited by dicoumarol.