Neuregulin 1

NRG1
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1HAE, 1HAF, 1HRE, 1HRF, 3U7U
Identifiers
Aliases	NRG1, ARIA, GGF, GGF2, HGL, HRG, HRG1, HRGA, MST131, MSTP131, NDF, NRG1-IT2, SMDF, neuregulin 1
External IDs	OMIM: 142445; HomoloGene: 8509; GeneCards: NRG1; OMA:NRG1 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	32,855,666 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; oocyte; ; secondary oocyte; ; monocyte; ; granulocyte; ; stromal cell of endometrium; ; spinal ganglia; ; gonad; ; endothelial cell;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transmembrane receptor protein tyrosine kinase activator activity; protein tyrosine kinase activator activity; signaling receptor binding; cytokine activity; transcription coregulator activity; growth factor activity; protein binding; chemorepellent activity; receptor tyrosine kinase binding; ErbB-2 class receptor binding; protein tyrosine kinase activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; ErbB-3 class receptor binding; integrin binding;
Cellular component	cytoplasm; membrane; synapse; extracellular region; nucleus; apical plasma membrane; integral component of membrane; neuromuscular junction; plasma membrane; axon; cell body; integral component of plasma membrane; dendrite; axolemma; external side of plasma membrane; nucleoplasm; extracellular space; glutamatergic synapse; GABA-ergic synapse;
Biological process	cardiac conduction system development; embryo development; positive regulation of Ras protein signal transduction; muscle organ development; oligodendrocyte differentiation; positive regulation of dendritic spine development; mammary gland development; axon ensheathment; cell communication; chemorepulsion involved in interneuron migration from the subpallium to the cortex; positive regulation of cardiac muscle cell proliferation; positive regulation of protein localization to cell surface; positive regulation of striated muscle cell differentiation; cell population proliferation; locomotory behavior; negative regulation of protein catabolic process; transmembrane receptor protein tyrosine kinase signaling pathway; cardiac muscle cell differentiation; endocardial cell differentiation; heart development; positive regulation of cell growth; cardiac muscle cell myoblast differentiation; positive regulation of peptidyl-tyrosine phosphorylation; synapse assembly; positive regulation of cardiac muscle cell differentiation; positive regulation of axon extension; peripheral nervous system development; startle response; regulation of protein heterodimerization activity; wound healing; glial cell differentiation; nervous system development; ventricular trabecula myocardium morphogenesis; glial cell fate commitment; negative regulation of cardiac muscle cell apoptotic process; negative regulation of transcription, DNA-templated; regulation of protein homodimerization activity; neurotransmitter receptor metabolic process; positive regulation of protein kinase activity; negative regulation of neuron migration; neurogenesis; neural crest cell development; MAPK cascade; positive regulation of calcineurin-NFAT signaling cascade; positive regulation of myelination; brain development; negative regulation of secretion; cell morphogenesis; regulation of cell differentiation; ventricular cardiac muscle cell differentiation; positive regulation of phosphatidylinositol 3-kinase signaling; neuron fate commitment; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; cell migration; positive regulation of cell adhesion; positive regulation of transcription by RNA polymerase II; phosphatidylinositol phosphate biosynthetic process; positive regulation of gene expression; positive regulation of cell population proliferation; ERBB signaling pathway; activation of protein kinase B activity; regulation of cell motility; peptidyl-tyrosine phosphorylation; positive regulation of protein tyrosine kinase activity; ERBB2 signaling pathway; activation of transmembrane receptor protein tyrosine kinase activity; cardiac muscle tissue development; ERBB3 signaling pathway; regulation of signaling receptor activity; positive regulation of protein kinase B signaling; ERBB4 signaling pathway; positive regulation of peptidyl-tyrosine autophosphorylation; myelination in peripheral nervous system; intracellular signal transduction; postsynapse to nucleus signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	3084
	n/a
	ENSG00000157168
	n/a
	Q02297; Q7RTW3
	n/a
NM_001159995; NM_001159996; NM_001159999; NM_001160001; NM_001160002;
	NM_001160004; NM_001160005; NM_001160007; NM_001160008; NM_004495; NM_013956; NM_013957; NM_013958; NM_013959; NM_013960; NM_013962; NM_013964; NM_001322197; NM_001322201; NM_001322202; NM_001322205; NM_001322206; NM_001322207
	n/a
NP_001153467; NP_001153468; NP_001153471; NP_001153473; NP_001153474;
	NP_001153476; NP_001153477; NP_001153479; NP_001153480; NP_001309126; NP_001309130; NP_001309131; NP_001309134; NP_001309135; NP_001309136; NP_004486; NP_039250; NP_039251; NP_039252; NP_039253; NP_039254; NP_039256; NP_039258; NP_039251.2; NP_001153471.1; NP_001309130.1
	n/a
	Wikidata
View/Edit Human

Neuregulin 1, or NRG1, is a gene of the epidermal growth factor family that in humans is encoded by the NRG1 gene. NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. Neuregulin 1 is produced in numerous isoforms by alternative splicing, which allows it to perform a wide variety of functions. It is essential for the normal development of the nervous system and the heart.