Neurotrophin-3

NTF3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1B8K, 1BND, 1NT3, 3BUK
Identifiers
Aliases	NTF3, HDNF, NGF-2, NGF2, NT-3, NT3, neurotrophin 3
External IDs	OMIM: 162660; MGI: 97380; HomoloGene: 1896; GeneCards: NTF3; OMA:NTF3 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	5,521,536 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	126,143,873 bp
RNA expression pattern
	Top expressed in
	popliteal artery; ; tibial arteries; ; right coronary artery; ; ascending aorta; ; left coronary artery; ; Descending thoracic aorta; ; right ovary; ; left ovary; ; testicle; ; saphenous vein;
	Top expressed in
	external naris; ; ciliary body; ; ascending aorta; ; iris; ; corneal stroma; ; conjunctival fornix; ; maxillary prominence; ; substantia nigra; ; pineal gland; ; medullary collecting duct;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	neurotrophin p75 receptor binding; neurotrophin receptor binding; chemoattractant activity; growth factor activity; signaling receptor binding; protein binding;
Cellular component	cytoplasmic vesicle; extracellular region; extracellular space; synaptic vesicle; axon; dendrite;
Biological process	regulation of apoptotic process; negative regulation of neuron apoptotic process; regulation of neuron differentiation; activation of protein kinase B activity; neuron projection morphogenesis; activation of GTPase activity; positive regulation of receptor internalization; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of cell migration; cell-cell signaling; positive regulation of peptidyl-serine phosphorylation; induction of positive chemotaxis; negative regulation of peptidyl-tyrosine phosphorylation; positive regulation of cell population proliferation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of actin cytoskeleton reorganization; signal transduction; positive chemotaxis; nervous system development; regulation of signaling receptor activity; positive regulation of phospholipase C activity; positive regulation of phosphatidylinositol 3-kinase signaling; peripheral nervous system development; memory; nerve development; nerve growth factor signaling pathway; modulation of chemical synaptic transmission; positive regulation of neurotrophin TRK receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	4908
	18205
	ENSG00000185652
	ENSMUSG00000049107
	P20783
	P20181
	NM_001102654; NM_002527
	NM_001164034; NM_001164035; NM_008742
	NP_001096124; NP_002518
	NP_001157506; NP_001157507; NP_032768
	Wikidata
View/Edit Human	View/Edit Mouse

Neurotrophin-3 is a protein that in humans is encoded by the NTF3 gene.

The protein encoded by this gene, NT-3, is a neurotrophic factor in the NGF (Nerve Growth Factor) family of neurotrophins. It is a protein growth factor which has activity on certain neurons of the peripheral and central nervous system; it helps to support the survival and differentiation of existing neurons, and encourages the growth and differentiation of new neurons and synapses. NT-3 was the third neurotrophic factor to be characterized, after nerve growth factor (NGF) and BDNF (Brain Derived Neurotrophic Factor).