Tropomyosin receptor kinase C

NTRK3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WWC, 3V5Q, 4YMJ
Identifiers
Aliases	NTRK3, GP145-TrkC, TRKC, gp145(trkC), neurotrophic receptor tyrosine kinase 3
External IDs	OMIM: 191316; MGI: 97385; HomoloGene: 49183; GeneCards: NTRK3; OMA:NTRK3 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	88,256,791 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	78,738,012 bp
RNA expression pattern
	Top expressed in
	Brodmann area 10; ; Brodmann area 23; ; popliteal artery; ; tibial arteries; ; frontal pole; ; middle temporal gyrus; ; paraflocculus of cerebellum; ; right coronary artery; ; spinal ganglia; ; middle frontal gyrus;
	Top expressed in
	ascending aorta; ; subiculum; ; cerebellar vermis; ; lobe of cerebellum; ; aortic valve; ; lumbar spinal ganglion; ; dorsomedial hypothalamic nucleus; ; olfactory tubercle; ; ventral tegmental area; ; paraventricular nucleus of hypothalamus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; protein tyrosine kinase activity; neurotrophin binding; protein kinase activity; transferase activity; transmembrane receptor protein tyrosine kinase activity; kinase activity; neurotrophin receptor activity; GPI-linked ephrin receptor activity; ATP binding; p53 binding; protein binding; receptor tyrosine kinase; transmembrane signaling receptor activity;
Cellular component	cytoplasm; integral component of membrane; membrane; receptor complex; integral component of plasma membrane; plasma membrane; glutamatergic synapse; integral component of postsynaptic membrane; axon;
Biological process	circadian rhythm; positive regulation of peptidyl-serine phosphorylation; ephrin receptor signaling pathway; response to ethanol; activation of protein kinase B activity; positive regulation of synapse assembly; multicellular organism development; positive regulation of actin cytoskeleton reorganization; positive regulation of cell migration; response to corticosterone; protein autophosphorylation; negative regulation of cell death; heart development; positive regulation of apoptotic process; peptidyl-tyrosine phosphorylation; cochlea development; nervous system development; positive regulation of gene expression; negative regulation of protein phosphorylation; activation of GTPase activity; protein phosphorylation; neurotrophin signaling pathway; cellular response to retinoic acid; neuron fate specification; positive regulation of axon extension involved in regeneration; positive regulation of cell population proliferation; modulation by virus of host transcription; lens fiber cell differentiation; mechanoreceptor differentiation; response to axon injury; positive regulation of positive chemotaxis; cell differentiation; negative regulation of astrocyte differentiation; positive regulation of protein phosphorylation; neuron migration; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of phospholipase C activity; positive regulation of phosphatidylinositol 3-kinase signaling; regulation of postsynaptic density assembly; regulation of presynapse assembly; negative regulation of signal transduction; positive regulation of neuron projection development; neuronal action potential propagation; myelination in peripheral nervous system; negative regulation of apoptotic process; positive regulation of ERK1 and ERK2 cascade; cellular response to nerve growth factor stimulus; regulation of MAPK cascade; positive regulation of MAPK cascade; positive regulation of neurotrophin TRK receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	4916
	18213
	ENSG00000140538
	ENSMUSG00000059146
	Q16288
	Q6VNS1
NM_001007156; NM_001012338; NM_001243101; NM_002530; NM_001320134;
	NM_001320135; NM_001375810; NM_001375811; NM_001375812; NM_001375813; NM_001375814
	NM_008746; NM_182809
NP_001007157; NP_001012338; NP_001230030; NP_001307063; NP_001307064;
	NP_002521; NP_001362739; NP_001362740; NP_001362741; NP_001362742; NP_001362743; NP_002521.2
	NP_032772; NP_877961
	Wikidata
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Tropomyosin receptor kinase C (TrkC), also known as NT-3 growth factor receptor, neurotrophic tyrosine kinase receptor type 3, or TrkC tyrosine kinase is a protein that in humans is encoded by the NTRK3 gene.

TrkC is the high affinity catalytic receptor for the neurotrophin NT-3 (neurotrophin-3). As such, TrkC mediates the multiple effects of this neurotrophic factor, which includes neuronal differentiation and survival.

The TrkC receptor is part of the large family of receptor tyrosine kinases. A "tyrosine kinase" is an enzyme which is capable of adding a phosphate group to the certain tyrosines on target proteins, or "substrates". A receptor tyrosine kinase is a "tyrosine kinase" which is located at the cellular membrane, and is activated by binding of a ligand via its extracellular domain. Other example of tyrosine kinase receptors include the insulin receptor, the IGF-1 receptor, the MuSK protein receptor, the vascular endothelial growth factor (VEGF) receptor, etc. The "substrate" proteins which are phosphorylated by TrkC include PI3 kinase.