Nucleoporin 153

NUP153
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	2EBQ, 2EBR, 2EBV, 2GQE, 4U0C, 4U0D
Identifiers
Aliases	NUP153, HN153, nucleoporin 153kDa, nucleoporin 153
External IDs	OMIM: 603948; MGI: 2385621; HomoloGene: 68442; GeneCards: NUP153; OMA:NUP153 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	17,706,925 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	46,881,416 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; epithelium of nasopharynx; ; cartilage tissue; ; tibia; ; germinal epithelium; ; Epithelium of choroid plexus; ; amniotic fluid; ; skin of thigh; ; parietal pleura; ; Skeletal muscle tissue of rectus abdominis;
	Top expressed in
	tail of embryo; ; primitive streak; ; genital tubercle; ; Gonadal ridge; ; ciliary body; ; Paneth cell; ; abdominal wall; ; medial ganglionic eminence; ; mandibular prominence; ; spermatid;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; protein-membrane adaptor activity; metal ion binding; protein binding; identical protein binding; nuclear localization sequence binding; structural constituent of nuclear pore;
Cellular component	nuclear membrane; nuclear periphery; membrane; nuclear pore; nucleoplasm; nucleolus; nuclear inclusion body; nuclear pore nuclear basket; nucleus; nuclear pore central transport channel; cytosol; host cell;
Biological process	mRNA transport; nuclear pore complex assembly; viral penetration into host nucleus; protein transport; viral entry into host cell; viral process; negative regulation of RNA export from nucleus; mRNA export from nucleus; protein import into nucleus; regulation of glycolytic process; tRNA export from nucleus; protein sumoylation; viral transcription; regulation of gene silencing by miRNA; intracellular transport of virus; regulation of cellular response to heat;
	Sources:Amigo / QuickGO
Orthologs
	9972
	218210
	ENSG00000124789
	ENSMUSG00000021374
	P49790
	n/a
	NM_001278209; NM_001278210; NM_005124
	NM_175749
	NP_001265138; NP_001265139; NP_005115
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Nucleoporin 153 (Nup153) is a protein which in humans is encoded by the NUP153 gene. It is an essential component of the basket of nuclear pore complexes (NPCs) in vertebrates, and is required for the anchoring of NPCs. It also acts as the docking site of an importing karyopherin. On the cytoplasmic side of the NPC, Nup358 fulfills an analogous role.