Nebulette

NEBL
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4F14
Identifiers
Aliases	NEBL, nebulette, LASP2, LNEBL
External IDs	OMIM: 605491; MGI: 1921353; HomoloGene: 31379; GeneCards: NEBL; OMA:NEBL - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	21,174,187 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	17,731,464 bp
RNA expression pattern
	Top expressed in
	right ventricle; ; myocardium; ; myocardium of left ventricle; ; optic nerve; ; cardiac muscle tissue of right atrium; ; apex of heart; ; glomerulus; ; metanephric glomerulus; ; right auricle of heart; ; Brodmann area 23;
	Top expressed in
	interventricular septum; ; atrium; ; myocardium of ventricle; ; atrioventricular valve; ; vestibular sensory epithelium; ; ciliary body; ; right lung lobe; ; left lung lobe; ; mammillary body; ; deep cerebellar nuclei;
	More reference expression data
	n/a
Gene ontology
Molecular function	filamin binding; cytoskeletal protein binding; actin filament binding; actin binding; structural constituent of muscle; tropomyosin binding; protein binding;
Cellular component	cytoplasm; Z discdkac; extracellular exosome; I band; stress fiber;
Biological process	cardiac muscle thin filament assembly;
	Sources:Amigo / QuickGO
Orthologs
	10529
	74103
	ENSG00000078114
	ENSMUSG00000053702
	O76041; Q5JUU7
	Q9DC07; Q0II04
	NM_001173484; NM_006393; NM_016365; NM_213569
	NM_028757; NM_001362722
NP_001166955; NP_006384; NP_998734; NP_001364251; NP_001364252;
	NP_001364253; NP_001364254; NP_001364255; NP_001364256; NP_001364257
	NP_083033.1; NP_083033; NP_001349651
	Wikidata
View/Edit Human	View/Edit Mouse

Nebulette is a cardiac-specific isoform belonging to the nebulin family of proteins. It is encoded by the NEBL gene. This family is composed of 5 members: nebulette, nebulin, N-RAP, LASP-1 and LASP-2. Nebulette localizes to Z-discs of cardiac muscle and appears to regulate the length of actin thin filaments.