Neurotensin receptor
| neurotensin receptor 1 (high affinity) | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | NTSR1 | ||||||
| Alt. symbols | NTR | ||||||
| NCBI gene | 4923 | ||||||
| HGNC | 8039 | ||||||
| OMIM | 162651 | ||||||
| RefSeq | NM_002531 | ||||||
| UniProt | P30989 | ||||||
| Other data | |||||||
| Locus | Chr. 20 q13-20q13 | ||||||
| |||||||
| neurotensin receptor 2 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | NTSR2 | ||||||
| Alt. symbols | NTR2 | ||||||
| NCBI gene | 23620 | ||||||
| HGNC | 8040 | ||||||
| OMIM | 605538 | ||||||
| RefSeq | NM_012344 | ||||||
| UniProt | O95665 | ||||||
| Other data | |||||||
| Locus | Chr. 2 p25.1 | ||||||
| |||||||
| sortilin 1 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | SORT1 | ||||||
| Alt. symbols | Gp95, NT3 | ||||||
| NCBI gene | 6272 | ||||||
| HGNC | 11186 | ||||||
| OMIM | 602458 | ||||||
| RefSeq | NM_002959 | ||||||
| UniProt | Q99523 | ||||||
| Other data | |||||||
| Locus | Chr. 1 p21.3-1p13.1 | ||||||
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Neurotensin receptors are transmembrane receptors that bind the neurotransmitter neurotensin. Two of the receptors encoded by the NTSR1 and NTSR2 genes contain seven transmembrane helices and are G protein coupled. Numerous crystal structures have been reported for the neurotensin receptor 1 (NTS1). The third receptor has a single transmembrane domain and is encoded by the SORT1 gene.