Noggin (protein)

NOG
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1M4U
Identifiers
Aliases	NOG, Nog, SYM1, SYNS1, SYNS1A, noggin
External IDs	OMIM: 602991; MGI: 104327; HomoloGene: 3979; GeneCards: NOG; OMA:NOG - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	56,595,611 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	89,193,158 bp
RNA expression pattern
	Top expressed in
	retinal pigment epithelium; ; buccal mucosa cell; ; testicle; ; gonad; ; ventricular zone; ; ganglionic eminence; ; decidua; ; canal of the cervix; ; nucleus accumbens; ; stromal cell of endometrium;
	Top expressed in
	notochord; ; neural groove; ; neural fold; ; ventricular zone; ; phalanx of second toe; ; muscle of thigh; ; embryo; ; embryonic organizer; ; primary visual cortex; ; somite;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein homodimerization activity; protein binding; cytokine binding;
Cellular component	extracellular region; extracellular space;
Biological process	positive regulation of glomerulus development; pattern specification process; axial mesoderm development; skeletal system development; cell differentiation; ureteric bud development; negative regulation of astrocyte differentiation; pituitary gland development; positive regulation of branching involved in ureteric bud morphogenesis; lung morphogenesis; negative regulation of cartilage development; somatic stem cell population maintenance; fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation; positive regulation of epithelial cell proliferation; negative regulation of cytokine activity; neural plate morphogenesis; negative regulation of cell differentiation; anatomical structure formation involved in morphogenesis; mesoderm formation; negative regulation of apoptotic signaling pathway; embryonic digit morphogenesis; cellular response to BMP stimulus; wound healing; in utero embryonic development; BMP signaling pathway; negative regulation of gene expression; somite development; negative regulation of osteoblast differentiation; embryonic skeletal system development; nervous system development; axon guidance; negative regulation of BMP signaling pathway; regulation of BMP signaling pathway; multicellular organism development; prostatic bud formation; limb development; central nervous system development; cartilage development; neural tube closure; brain development; negative regulation of cell migration; notochord morphogenesis; cell differentiation in hindbrain; mesenchymal cell differentiation; regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation; neural tube development; spinal cord development; ureteric bud formation; epithelial to mesenchymal transition; middle ear morphogenesis; embryonic skeletal joint morphogenesis; urogenital system development; endoderm formation; negative regulation of cardiac muscle cell proliferation; motor neuron axon guidance; dorsal/ventral pattern formation; negative regulation of canonical Wnt signaling pathway; face morphogenesis; positive regulation of transcription by RNA polymerase II; negative regulation of transcription by RNA polymerase II; osteoblast differentiation; membranous septum morphogenesis; outflow tract morphogenesis; endocardial cushion morphogenesis; ventricular compact myocardium morphogenesis; endoderm development; positive regulation of gene expression; atrial cardiac muscle tissue morphogenesis; negative regulation of pathway-restricted SMAD protein phosphorylation; ventricular septum morphogenesis; BMP signaling pathway involved in heart development; heart trabecula morphogenesis; pharyngeal arch artery morphogenesis; negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation;
	Sources:Amigo / QuickGO
Orthologs
	9241
	18121
	ENSG00000183691
	ENSMUSG00000048616
	Q13253
	P97466
	NM_005450
	NM_008711
	NP_005441
	NP_032737
	Wikidata
View/Edit Human	View/Edit Mouse

Noggin, also known as NOG, is a protein that is involved in the development of many body tissues, including nerve tissue, muscles, and bones. In humans, noggin is encoded by the NOG gene. The amino acid sequence of human noggin is highly homologous to that of rat, mouse, and Xenopus (an aquatic frog genus).

Noggin is an inhibitor of several bone morphogenetic proteins (BMPs): it inhibits at least BMP2, 4, 5, 6, 7, 13, and 14.

The protein's name, which is a slang English-language word for "head", was coined in reference to its ability to produce embryos with large heads when exposed at high concentrations.