OAZ2

OAZ2
Identifiers
Aliases	OAZ2, AZ2, ornithine decarboxylase antizyme 2
External IDs	OMIM: 604152; MGI: 109492; HomoloGene: 31094; GeneCards: OAZ2; OMA:OAZ2 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	64,703,281 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	65,597,582 bp
RNA expression pattern
	Top expressed in
	left testis; ; right testis; ; monocyte; ; C1 segment; ; prefrontal cortex; ; Amygdala; ; nucleus accumbens; ; gastrocnemius muscle; ; cingulate gyrus; ; right frontal lobe;
	Top expressed in
	lung; ; muscle of thigh; ; quadriceps femoris muscle; ; skeletal muscle tissue; ; neural tube; ; dentate gyrus of hippocampal formation granule cell; ; Mesencephalon; ; Hypothalamus; ; heart; ; superior frontal gyrus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	ornithine decarboxylase inhibitor activity; protein binding;
Cellular component	cytosol; nucleus; cytoplasm;
Biological process	positive regulation of intracellular protein transport; polyamine biosynthetic process; polyamine metabolic process; negative regulation of polyamine transmembrane transport; negative regulation of catalytic activity; regulation of cellular amino acid metabolic process; positive regulation of protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	4947
	18247
	ENSG00000180304
	ENSMUSG00000040652
	O95190
	O08608
	NM_002537; NM_001301302
	NM_001301307; NM_010952
	NP_001288231; NP_002528
	NP_001288236; NP_035082
	Wikidata
View/Edit Human	View/Edit Mouse

Ornithine decarboxylase antizyme 2 is an enzyme that in humans is encoded by the OAZ2 gene.

Ornithine decarboxylase catalyzes the conversion of ornithine to putrescine in the first and apparently rate-limiting step in polyamine biosynthesis. The ornithine decarboxylase antizymes play a role in the regulation of polyamine synthesis by binding to and inhibiting ornithine decarboxylase. Antizyme expression is auto-regulated by polyamine-enhanced translational frameshifting. The antizyme encoded by this gene inhibits ornithine decarboxylase but does not accelerate its degradation.