Ornithine decarboxylase
| Ornithine decarboxylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
Ornithine decarboxylase dimer, Human | |||||||||
| Identifiers | |||||||||
| EC no. | 4.1.1.17 | ||||||||
| CAS no. | 9024-60-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
| ornithine decarboxylase | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | ODC1 | ||||||
| NCBI gene | 4953 | ||||||
| HGNC | 8109 | ||||||
| OMIM | 165640 | ||||||
| RefSeq | NM_002539 | ||||||
| UniProt | P11926 | ||||||
| Other data | |||||||
| EC number | 4.1.1.17 | ||||||
| Locus | Chr. 2 p25 | ||||||
| |||||||
The enzyme ornithine decarboxylase (EC 4.1.1.17, ODC) catalyzes the decarboxylation of ornithine (a product of the urea cycle) to form putrescine. This reaction is the committed step in polyamine synthesis. In humans, this protein has 461 amino acids and forms a homodimer.
In humans, ornithine decarboxylase (ODC) is expressed by the gene ODC1. The protein ODC is sometimes referred to as "ODC1" in research pertaining to humans and mice, but certain species such as Drosophila (dODC2), species of Solanaceae plant family (ODC2), and the lactic acid bacteria Paucilactobacillus wasatchensis (odc2) have been shown to have a second ODC gene.