OSBPL8

OSBPL8
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1V88
Identifiers
Aliases	OSBPL8, MST120, MSTP120, ORP8, OSBP10, oxysterol binding protein like 8
External IDs	OMIM: 606736; MGI: 2443807; HomoloGene: 68813; GeneCards: OSBPL8; OMA:OSBPL8 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	76,559,809 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	111,133,110 bp
RNA expression pattern
	Top expressed in
	lower lobe of lung; ; lactiferous duct; ; trabecular bone; ; endothelial cell; ; nipple; ; skin of hip; ; Achilles tendon; ; visceral pleura; ; trigeminal ganglion; ; superficial temporal artery;
	Top expressed in
	olfactory tubercle; ; zygote; ; nucleus accumbens; ; secondary oocyte; ; cumulus cell; ; olfactory epithelium; ; myocardium of ventricle; ; retinal pigment epithelium; ; interventricular septum; ; aortic valve;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	phosphatidylserine binding; cholesterol binding; phosphatidylinositol-4-phosphate binding; lipid binding; phospholipid transporter activity; sterol transporter activity; sterol binding;
Cellular component	integral component of membrane; nuclear membrane; endoplasmic reticulum membrane; membrane; cortical endoplasmic reticulum; endoplasmic reticulum; nucleus; cytosol; intracellular membrane-bounded organelle;
Biological process	activation of protein kinase B activity; positive regulation of protein kinase B signaling; lipid transport; protein localization to nuclear pore; phospholipid transport; negative regulation of cell migration; negative regulation of sequestering of triglyceride; positive regulation of insulin receptor signaling pathway; fat cell differentiation; phosphatidylserine acyl-chain remodeling; transport; sterol transport; positive regulation of glucose import;
	Sources:Amigo / QuickGO
Orthologs
	114882
	237542
	ENSG00000091039
	ENSMUSG00000020189
	Q9BZF1
	B9EJ86
	NM_001003712; NM_020841; NM_001319652; NM_001319653; NM_001319655
	NM_001003717; NM_175489
	NP_001003712; NP_001306581; NP_001306582; NP_001306584; NP_065892
	NP_001003717; NP_780698
	Wikidata
View/Edit Human	View/Edit Mouse

Oxysterol-binding protein-related protein 8 is a protein that in humans is encoded by the OSBPL8 gene.

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intravenous lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Two transcript variants encoding different isoforms have been found for this gene.