Oncostatin M

OSM
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1EVS
Identifiers
Aliases	OSM, Osm, OncoM, oncostatin M
External IDs	OMIM: 165095; MGI: 104749; HomoloGene: 10741; GeneCards: OSM; OMA:OSM - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	30,266,851 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	4,191,026 bp
RNA expression pattern
	Top expressed in
	bone marrow cells; ; monocyte; ; blood; ; nasal epithelium; ; appendix; ; granulocyte; ; gallbladder; ; upper lobe of left lung; ; abdominal wall; ; spleen;
	Top expressed in
	granulocyte; ; stroma of bone marrow; ; morula; ; blastocyst; ; submandibular gland; ; blood; ; mesenteric lymph nodes; ; thymus; ; spleen; ; gastrula;
	More reference expression data
	n/a
Gene ontology
Molecular function	cytokine activity; oncostatin-M receptor binding; growth factor activity;
Cellular component	extracellular region; extracellular space;
Biological process	oncostatin-M-mediated signaling pathway; positive regulation of peptidyl-serine phosphorylation; multicellular organism development; immune response; positive regulation of cell population proliferation; positive regulation of acute inflammatory response; regulation of growth; cell population proliferation; negative regulation of hormone secretion; positive regulation of cell division; positive regulation of MAPK cascade; negative regulation of cell population proliferation; positive regulation of transcription by RNA polymerase II; positive regulation of tyrosine phosphorylation of STAT protein; regulation of signaling receptor activity; positive regulation of peptidyl-tyrosine phosphorylation; cytokine-mediated signaling pathway; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of inflammatory response; positive regulation of protein kinase B signaling; regulation of hematopoietic stem cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	5008
	18413
	ENSG00000099985
	ENSMUSG00000058755
	P13725
	P53347
	NM_020530; NM_001319108
	NM_001013365
	NP_001306037; NP_065391
	NP_001013383
	Wikidata
View/Edit Human	View/Edit Mouse

Oncostatin M, also known as OSM, is a protein that in humans is encoded by the OSM gene.

OSM is a pleiotropic cytokine that belongs to the interleukin 6 group of cytokines. Of these cytokines it most closely resembles leukemia inhibitory factor (LIF) in both structure and function. As yet poorly defined, it is proving important in liver development, haematopoeisis, inflammation and possibly CNS development. It is also associated with bone formation and destruction.

OSM signals through cell surface receptors that contain the protein gp130. The type I receptor is composed of gp130 and LIFR, the type II receptor is composed of gp130 and OSMR.