OSR1

OSR1
Identifiers
Aliases	OSR1, ODD, odd-skipped related transcription factor 1, odd-skipped related transciption factor 1
External IDs	OMIM: 608891; MGI: 1344424; HomoloGene: 8035; GeneCards: OSR1; OMA:OSR1 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	19,358,623 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	9,631,500 bp
RNA expression pattern
	Top expressed in
	Descending thoracic aorta; ; ascending aorta; ; popliteal artery; ; tibial arteries; ; right coronary artery; ; minor salivary glands; ; left coronary artery; ; gastric mucosa; ; muscle layer of sigmoid colon; ; urinary bladder;
	Top expressed in
	ascending aorta; ; intermediate mesoderm; ; phalanx of second toe; ; aortic valve; ; body wall; ; internal carotid artery; ; lower lip; ; upper lip; ; genital tubercle; ; dermis;
	More reference expression data
	n/a
Gene ontology
Molecular function	metal ion binding; nucleic acid binding; protein serine/threonine kinase activity; protein binding; protein kinase binding; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding;
Cellular component	nucleus; cytosol; extrinsic component of membrane;
Biological process	pronephros development; cellular response to retinoic acid; metanephric glomerulus vasculature development; roof of mouth development; cell differentiation; specification of posterior mesonephric tubule identity; ureteric bud development; specification of anterior mesonephric tubule identity; regulation of transcription, DNA-templated; chondrocyte differentiation; negative regulation of nephron tubule epithelial cell differentiation; positive regulation of gastrulation; embryonic skeletal joint development; metanephric cap mesenchymal cell proliferation involved in metanephros development; positive regulation of bone mineralization; positive regulation of epithelial cell proliferation; embryonic skeletal limb joint morphogenesis; metanephric mesenchymal cell differentiation; posterior mesonephric tubule development; intermediate mesoderm development; embryonic digit morphogenesis; metanephric epithelium development; negative regulation of apoptotic process; negative regulation of transcription by RNA polymerase II; mesonephric duct morphogenesis; transcription, DNA-templated; stem cell differentiation; odontogenesis; mesonephros development; cell proliferation involved in kidney development; heart development; metanephric nephron tubule development; ureter urothelium development; positive regulation of gene expression; mesangial cell development; pattern specification involved in metanephros development; metanephric smooth muscle tissue development; renal vesicle progenitor cell differentiation; middle ear morphogenesis; embryonic skeletal joint morphogenesis; urogenital system development; metanephric mesenchyme morphogenesis; metanephros development; negative regulation of epithelial cell differentiation; metanephric interstitial fibroblast development; gonad development; embryonic forelimb morphogenesis; metanephric mesenchyme development; positive regulation of transcription by RNA polymerase II; embryonic hindlimb morphogenesis; osmosensory signaling pathway; peptidyl-threonine phosphorylation; negative regulation of creatine transmembrane transporter activity; negative regulation of sodium ion transmembrane transporter activity;
	Sources:Amigo / QuickGO
Orthologs
	130497
	23967
	ENSG00000143867
	ENSMUSG00000048387
	Q8TAX0
	Q9WVG7
	NM_145260
	NM_011859
	NP_660303
	NP_035989
	Wikidata
View/Edit Human	View/Edit Mouse

Protein odd-skipped-related 1 is a transcription factor that in humans is encoded by the OSR1 gene. The OSR1 and OSR2 transcription factors participate in the normal development of body parts such as the kidney.

Protein odd-skipped related 1 is a zinc-finger transcription factor that, in humans, is encoded by the OSR1 gene found on chromosome 2 (2p24.1) and in mice is encoded by the Osr1 gene. In mammals, OSR1 is involved in the development of the kidneys, heart and in the palate and is often coexpressed with OSR2. OSR1 and OSR2 are homologous to the Odd-skipped class transcription factors in Drosophila, encoded by odd, bowl, sob and arm.