Organic personality disorder

Organic personality disorder (OPD) or secondary personality change, is a condition described in the ICD-10 and ICD-11 respectively. It is characterized by a significant personality change featuring abnormal behavior due to an underlying traumatic brain injury or another pathophysiological medical condition affecting the brain. Abnormal behavior can include but is not limited to apathy, paranoia and disinhibition.

The DSM-5-TR, which is the latest edition of the DSM as of 2025, lists personality change due to another medical condition with the ICD-10-CM code F07.0, which corresponds to what the ICD-10 denotes as OPD.

In the ICD-10, it is described as a mental disorder and not included in the classification group of personality disorders. In the ICD-11, it is described as a syndrome.

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