PADI2

PADI2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4N20, 4N22, 4N24, 4N25, 4N26, 4N28, 4N2A, 4N2B, 4N2C, 4N2D, 4N2E, 4N2F, 4N2G, 4N2H, 4N2I, 4N2K, 4N2L, 4N2M, 4N2N
Identifiers
Aliases	PADI2, PAD-H19, PAD2, PDI2, peptidyl arginine deiminase 2
External IDs	OMIM: 607935; MGI: 1338892; HomoloGene: 7214; GeneCards: PADI2; OMA:PADI2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	17,119,451 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	140,679,897 bp
RNA expression pattern
	Top expressed in
	internal globus pallidus; ; C1 segment; ; glutes; ; inferior olivary nucleus; ; inferior ganglion of vagus nerve; ; middle frontal gyrus; ; external globus pallidus; ; subthalamic nucleus; ; gastrocnemius muscle; ; tibialis anterior muscle;
	Top expressed in
	vestibular membrane of cochlear duct; ; decidua; ; gastrula; ; saccule; ; lacrimal gland; ; digastric muscle; ; retinal pigment epithelium; ; sternocleidomastoid muscle; ; stria vascularis; ; vestibular sensory epithelium;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; estrogen receptor binding; hydrolase activity; protein-arginine deiminase activity; protein homodimerization activity; metal ion binding;
Cellular component	extracellular exosome; cytoplasm; cytosol; extracellular region; nucleus; azurophil granule lumen;
Biological process	negative regulation of chemokine-mediated signaling pathway; substantia nigra development; intracellular estrogen receptor signaling pathway; negative regulation of lymphocyte chemotaxis; chromatin organization; neutrophil degranulation; cellular response to leukemia inhibitory factor;
	Sources:Amigo / QuickGO
Orthologs
	11240
	18600
	ENSG00000117115
	ENSMUSG00000028927
	Q9Y2J8
	Q08642
	NM_007365
	NM_008812
	NP_031391
	NP_032838
	Wikidata
View/Edit Human	View/Edit Mouse

Protein-arginine deiminase type-2 is an enzyme that in humans is encoded by the PADI2 gene.

This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type II enzyme is the most widely expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages.

This enzyme is thought to play a role in the onset and progression of neurodegenerative human disorders, including Alzheimer disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis. This gene exists in a cluster with four other paralogous genes.