PCGF6

PCGF6
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DJB
Identifiers
Aliases	PCGF6, MBLR, RNF134, polycomb group ring finger 6
External IDs	OMIM: 607816; MGI: 1918291; HomoloGene: 12378; GeneCards: PCGF6; OMA:PCGF6 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	103,351,144 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	47,039,345 bp
RNA expression pattern
	Top expressed in
	gonad; ; ventricular zone; ; gastrocnemius muscle; ; testicle; ; skeletal muscle tissue; ; stromal cell of endometrium; ; smooth muscle tissue; ; ganglionic eminence; ; tibial arteries; ; muscle layer of sigmoid colon;
	Top expressed in
	zygote; ; spermatocyte; ; primary oocyte; ; secondary oocyte; ; epiblast; ; seminiferous tubule; ; primitive streak; ; Rostral migratory stream; ; embryo; ; tail of embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA-binding transcription factor activity; DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; protein binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; metal ion binding;
Cellular component	nucleus; PcG protein complex; nucleoplasm; PRC1 complex;
Biological process	regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; histone H2A-K119 monoubiquitination; negative regulation of G0 to G1 transition; negative regulation of transcription, DNA-templated; inactivation of X chromosome by genetic imprinting;
	Sources:Amigo / QuickGO
Orthologs
	84108
	71041
	ENSG00000156374
	ENSMUSG00000025050
	Q9BYE7
	Q99NA9
	NM_001011663; NM_032154
	NM_027654; NM_001360632
	NP_001011663; NP_115530
	NP_081930; NP_001347561
	Wikidata
View/Edit Human	View/Edit Mouse

Polycomb group RING finger protein 6 is a protein that in humans is encoded by the PCGF6 gene.

The protein encoded by this gene contains a RING finger motif, which is most closely related to those of polycomb group (PcG) proteins RNF110/MEL-18 and BMI1. PcG proteins are known to form protein complexes and function as transcription repressors. This protein has been shown to interact with some PcG proteins and act as a transcription repressor. The activity of this protein is found to be regulated by cell cycle dependent phosphorylation. Alternatively spliced transcript variants encoding different isoforms have been identified.