PFDN1

PFDN1
Identifiers
Aliases	PFDN1, PDF, PFD1, prefoldin subunit 1
External IDs	OMIM: 604897; MGI: 1914449; HomoloGene: 37644; GeneCards: PFDN1; OMA:PFDN1 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	140,303,113 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	36,587,577 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; ganglionic eminence; ; ventricular zone; ; muscle of thigh; ; islet of Langerhans; ; gonad; ; prefrontal cortex; ; C1 segment; ; apex of heart; ; right frontal lobe;
	Top expressed in
	ventromedial nucleus; ; mammillary body; ; lateral hypothalamus; ; lateral septal nucleus; ; facial motor nucleus; ; external carotid artery; ; maxillary prominence; ; anterior amygdaloid area; ; lateral geniculate nucleus; ; arcuate nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; unfolded protein binding; protein folding chaperone activity;
Cellular component	prefoldin complex; cytoplasm;
Biological process	regulation of transcription, DNA-templated; protein folding; cytoskeleton organization;
	Sources:Amigo / QuickGO
Orthologs
	5201
	67199
	ENSG00000113068
	ENSMUSG00000024346
	O60925
	Q9CWM4; Q9CQF7
	NM_002622
	NM_026027
	NP_002613
	NP_080303
	Wikidata
View/Edit Human	View/Edit Mouse

Prefoldin subunit 1 is a protein that in humans is encoded by the PFDN1 gene.

This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled coils.