PHD finger
| PHD-finger | |||||||||
|---|---|---|---|---|---|---|---|---|---|
PHD zinc finger. Zinc atoms shown in grey | |||||||||
| Identifiers | |||||||||
| Symbol | PHD | ||||||||
| Pfam | PF00628 | ||||||||
| Pfam clan | CL0390 | ||||||||
| InterPro | IPR019787 | ||||||||
| PROSITE | PS50016 | ||||||||
| SCOP2 | 1f62 / SCOPe / SUPFAM | ||||||||
| OPM superfamily | 59 | ||||||||
| OPM protein | 1vfy | ||||||||
| |||||||||
The PHD finger was discovered in 1993 as a Cys4-His-Cys3 motif in the plant homeodomain (hence PHD) proteins HAT3.1 in Arabidopsis and maize ZmHox1a. The PHD zinc finger motif resembles the metal binding RING domain (Cys3-His-Cys4) and FYVE domain. It occurs as a single finger, but often in clusters of two or three, and it also occurs together with other domains, such as the chromodomain and the bromodomain.