PIP5K1C

PIP5K1C
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2G35, 3H1Z, 3H85
Identifiers
Aliases	PIP5K1C, LCCS3, PIP5K-GAMMA, PIP5K1-gamma, PIP5Kgamma, phosphatidylinositol-4-phosphate 5-kinase type 1 gamma
External IDs	OMIM: 606102; MGI: 1298224; HomoloGene: 69032; GeneCards: PIP5K1C; OMA:PIP5K1C - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	3,700,468 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	81,319,973 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; decidua; ; Brodmann area 10; ; left testis; ; right testis; ; paraflocculus of cerebellum; ; right frontal lobe; ; cerebellar vermis; ; middle temporal gyrus; ; stromal cell of endometrium;
	Top expressed in
	superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; prefrontal cortex; ; cerebellar cortex; ; external carotid artery; ; internal carotid artery; ; primary visual cortex; ; Rostral migratory stream; ; granulocyte; ; neural layer of retina;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; kinase activity; protein binding; phosphatidylinositol phosphate kinase activity; ATP binding; phosphatidylinositol-3,4-bisphosphate 5-kinase activity; 1-phosphatidylinositol-4-phosphate 5-kinase activity; 1-phosphatidylinositol-3-phosphate 4-kinase activity;
Cellular component	cytoplasm; cell projection; membrane; focal adhesion; adherens junction; plasma membrane; ruffle membrane; cell junction; uropod; phagocytic cup; endomembrane system; nucleus; presynapse; synapse; nucleoplasm; cytosol; endosome membrane;
Biological process	endocytosis; phosphatidylinositol metabolic process; adherens junction assembly; phosphorylation; synaptic vesicle exocytosis; neutrophil chemotaxis; chemotaxis; clathrin-dependent endocytosis; phosphatidylinositol phosphate biosynthetic process; cell adhesion; synaptic vesicle endocytosis; phagocytosis; phosphatidylinositol biosynthetic process; actin cytoskeleton organization; exocytosis; regulation of phosphatidylinositol 3-kinase signaling; membrane organization; cell-cell adhesion;
	Sources:Amigo / QuickGO
Orthologs
	23396
	18717
	ENSG00000186111
	ENSMUSG00000034902
	O60331
	O70161
	NM_001195733; NM_001300849; NM_012398
	NM_001146687; NM_001293646; NM_001293647; NM_008844
	NP_001182662; NP_001287778; NP_036530
	NP_001140159; NP_001280575; NP_001280576; NP_032870
	Wikidata
View/Edit Human	View/Edit Mouse

Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma is an enzyme that in humans is encoded by the PIP5K1C gene.

This gene encodes a member of the type I phosphatidylinositol-4-phosphate 5-kinase family of enzymes. A similar protein in mice is found in synapses and focal adhesion plaques, and binds the FERM domain of talin through its C-terminus.