PIR (gene)

PIR
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4ERO, 4EWD, 4GUL, 1J1L, 4EWA, 4HLT, 3ACL, 4EWE
Identifiers
Aliases	PIR, pirin
External IDs	OMIM: 300931; MGI: 1916906; HomoloGene: 2717; GeneCards: PIR; OMA:PIR - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	15,493,564 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	163,156,007 bp
RNA expression pattern
	Top expressed in
	C1 segment; ; gonad; ; right lung; ; right adrenal gland; ; right adrenal cortex; ; urinary bladder; ; olfactory zone of nasal mucosa; ; left adrenal gland; ; left adrenal cortex; ; islet of Langerhans;
	Top expressed in
	esophagus; ; lumbar spinal ganglion; ; olfactory epithelium; ; embryo; ; left lobe of liver; ; lip; ; right lung; ; conjunctival fornix; ; transitional epithelium of urinary bladder; ; right lung lobe;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	oxidoreductase activity; protein binding; transcription coregulator activity; dioxygenase activity; metal ion binding; quercetin 2,3-dioxygenase activity;
Cellular component	cytoplasm; nucleus; cytosol; nucleoplasm;
Biological process	myeloid cell differentiation; regulation of transcription, DNA-templated; monocyte differentiation; transcription by RNA polymerase II; transcription, DNA-templated; digestion; regulation of nucleic acid-templated transcription;
	Sources:Amigo / QuickGO
Orthologs
	8544
	69656
	ENSG00000087842
	ENSMUSG00000031379
	O00625
	Q9D711
	NM_003662; NM_001018109
	NM_001301402; NM_027153
	NP_001018119; NP_003653
	NP_001288331; NP_081429
	Wikidata
View/Edit Human	View/Edit Mouse

Pirin is a protein that in humans is encoded by the PIR gene.

This gene encodes a member of the cupin superfamily. The encoded protein is a Fe(II)-containing nuclear protein expressed in all tissues of the body and concentrated within dot-like subnuclear structures. Interactions with nuclear factor I/CCAAT box transcription factor as well as B cell lymphoma 3-encoded oncoprotein suggest the encoded protein may act as a transcriptional cofactor and be involved in the regulation of DNA transcription and replication. Alternatively spliced transcript variants have been described.