CXCL7

PPBP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1TVX, 1F9P, 1NAP
Identifiers
Aliases	PPBP, B-TG1, Beta-TG, CTAP-III, CTAP3, CTAPIII, CXCL7, LA-PF4, LDGF, MDGF, NAP-2, PBP, SCYB7, TC1, TC2, TGB, TGB1, THBGB, THBGB1, pro-platelet basic protein
External IDs	OMIM: 121010; MGI: 1888712; HomoloGene: 136759; GeneCards: PPBP; OMA:PPBP - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	73,988,190 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	90,917,922 bp
RNA expression pattern
	Top expressed in
	monocyte; ; trabecular bone; ; granulocyte; ; blood; ; bone marrow cells; ; periodontal fiber; ; spleen; ; decidua; ; right lung; ; testicle;
	Top expressed in
	tibiofemoral joint; ; umbilical cord; ; blood; ; spleen; ; fetal liver hematopoietic progenitor cell; ; body of femur; ; right lung lobe; ; human fetus; ; endocardial cushion; ; yolk sac;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	growth factor activity; cytokine activity; glucose transmembrane transporter activity; CXCR chemokine receptor binding; chemokine activity; protein binding;
Cellular component	platelet alpha granule lumen; extracellular region; extracellular space; tertiary granule lumen; platelet alpha granule;
Biological process	response to lipopolysaccharide; regulation of cell population proliferation; chemotaxis; positive regulation of cell division; platelet degranulation; defense response to bacterium; inflammatory response; immune response; chemokine-mediated signaling pathway; defense response; positive regulation of neutrophil chemotaxis; antimicrobial humoral immune response mediated by antimicrobial peptide; regulation of signaling receptor activity; neutrophil degranulation; cell chemotaxis; G protein-coupled receptor signaling pathway; glucose transmembrane transport; neutrophil chemotaxis; leukocyte chemotaxis; cellular response to lipopolysaccharide;
	Sources:Amigo / QuickGO
Orthologs
	5473
	57349
	ENSG00000163736
	ENSMUSG00000029372
	P02775
	Q9EQI5
	NM_002704
	NM_023785
	NP_002695
	NP_076274
	Wikidata
View/Edit Human	View/Edit Mouse

Chemokine (C-X-C motif) ligand 7 (CXCL7) is a human gene.

The encoded protein, Chemokine (C-X-C motif) ligand is a small cytokine belonging to the CXC chemokine family. It is an isoform of Beta-Thromboglobulin or Pro-Platelet basic protein (PPBP).

It is a protein that is released in large amounts from platelets following their activation. It stimulates various processes including mitogenesis, synthesis of extracellular matrix, glucose metabolism and synthesis of plasminogen activator.