Peptidylprolyl isomerase D

PPID
Identifiers
Aliases	PPID, CYP-40, CYPD, peptidylprolyl isomerase D
External IDs	OMIM: 601753; MGI: 1914988; HomoloGene: 31283; GeneCards: PPID; OMA:PPID - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	158,723,396 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	79,510,957 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; muscle of thigh; ; gastrocnemius muscle; ; mucosa of transverse colon; ; gonad; ; Skeletal muscle tissue of rectus abdominis; ; right adrenal cortex; ; rectum; ; body of tongue; ; left ventricle;
	Top expressed in
	tail of embryo; ; epiblast; ; cingulate gyrus; ; embryo; ; embryo; ; genital tubercle; ; neural tube; ; ventricular zone; ; Amygdala; ; otic vesicle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	Hsp90 protein binding; heat shock protein binding; transcription factor binding; isomerase activity; peptidyl-prolyl cis-trans isomerase activity; Hsp70 protein binding; protein binding; estrogen receptor binding; cyclosporin A binding; unfolded protein binding;
Cellular component	cytoplasm; nucleolus; nucleus; cytosol; nucleoplasm; mitochondrion;
Biological process	chaperone-mediated protein folding; cellular response to UV-A; viral release from host cell; lipid droplet organization; negative regulation of transcription by RNA polymerase II; protein folding; positive regulation of protein secretion; positive regulation of apoptotic process; protein transport; positive regulation of viral genome replication; apoptotic process; protein-containing complex assembly; protein peptidyl-prolyl isomerization; protein refolding; negative regulation of apoptotic process; regulation of mitochondrial membrane potential;
	Sources:Amigo / QuickGO
Orthologs
	5481
	67738
	ENSG00000171497
	ENSMUSG00000027804
	Q08752
	Q9CR16
	NM_005038
	NM_026352; NM_001356326
	NP_005029
	NP_080628; NP_001343255
	Wikidata
View/Edit Human	View/Edit Mouse

Peptidylprolyl isomerase D (cyclophilin D), also known as PPID, is an enzyme which in humans is encoded by the PPID gene on chromosome 4. As a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family, this protein catalyzes the cis-trans isomerization of proline imidic peptide bonds, which allows it to facilitate folding or repair of proteins. In addition, PPID participates in many biological processes, including mitochondrial metabolism, apoptosis, redox, and inflammation, as well as in related diseases and conditions, such as ischemic reperfusion injury, AIDS, and cancer.