PRIM2

PRIM2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3L9Q, 3Q36, 4BPU, 4BPW, 4BPX, 4RR2, 5F0Q, 5EXR, 5F0S
Identifiers
Aliases	PRIM2, PRIM2A, p58, primase (DNA) subunit 2, DNA primase subunit 2
External IDs	OMIM: 176636; MGI: 97758; HomoloGene: 731; GeneCards: PRIM2; OMA:PRIM2 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	57,646,850 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	33,708,876 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; gonad; ; ganglionic eminence; ; Achilles tendon; ; ventricular zone; ; testicle; ; oocyte; ; epithelium of colon; ; stromal cell of endometrium; ; rectum;
	Top expressed in
	fetal liver hematopoietic progenitor cell; ; secondary oocyte; ; genital tubercle; ; maxillary prominence; ; primary oocyte; ; mandibular prominence; ; medial ganglionic eminence; ; tail of embryo; ; cumulus cell; ; spermatocyte;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA-directed 5'-3' RNA polymerase activity; transferase activity; DNA binding; 4 iron, 4 sulfur cluster binding; iron-sulfur cluster binding; nucleotidyltransferase activity; metal ion binding; single-stranded DNA binding; DNA-directed DNA polymerase activity; DNA primase activity; protein binding;
Cellular component	nucleoplasm; alpha DNA polymerase:primase complex;
Biological process	DNA replication; DNA replication, synthesis of RNA primer; DNA biosynthetic process; telomere maintenance via semi-conservative replication; G1/S transition of mitotic cell cycle; DNA replication initiation;
	Sources:Amigo / QuickGO
Orthologs
	5558
	19076
	ENSG00000146143
	ENSMUSG00000026134
	P49643
	P33610
	NM_000947; NM_001282487; NM_001282488
	NM_008922
	NP_000938; NP_001269416; NP_001269417
	NP_032948
	Wikidata
View/Edit Human	View/Edit Mouse

DNA primase large subunit is an enzyme that in humans is encoded by the PRIM2 gene.

The replication of DNA in eukaryotic cells is carried out by a complex chromosomal replication apparatus, in which DNA polymerase alpha and primase are two key enzymatic components. Primase, which is a heterodimer of a small subunit and a large subunit, synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. The protein encoded by this gene is the large, 58 kDa primase subunit.