Phencyclidine

Phencyclidine
Clinical data
Trade names	Sernyl, Sernylan (both discontinued)
Other names	CI-395; Phenylcyclohexylpiperidine; "Angel dust"
AHFS/Drugs.com	phencyclidine
Dependence; liability	Physical: Low Psychological: Moderate
Addiction; liability	Variable, reported from low to high
Routes of; administration	Smoking, injection, snorted, by mouth
Drug class	NMDA receptor antagonists; General anesthetics; Dissociative hallucinogens
ATC code	None;
Legal status
Legal status	AU: S8 (Controlled drug); BR: Class A3 (Psychoactive drugs); CA: Schedule I; DE: Anlage I (Authorized scientific use only); NZ: Class A; UK: Class A; US: Schedule II; UN: Psychotropic Schedule II; Tabella I in Italy;
Pharmacokinetic data
Metabolism	Oxidative hydroxylation in liver by CYP450 enzymes, glucuronidation
Metabolites	PCHP, PPC, PCAA
Onset of action	2–60 min
Elimination half-life	7–46 hours
Duration of action	6–48 hours
Excretion	Urine
Identifiers
	IUPAC name 1-(1-Phenylcyclohexyl)piperidine;
CAS Number	77-10-1 ;
PubChem CID	6468;
IUPHAR/BPS	4282;
DrugBank	DB03575 ;
ChemSpider	6224 ;
UNII	J1DOI7UV76;
KEGG	C07575 ;
ChEBI	CHEBI:8058 ;
ChEMBL	ChEMBL275528 ;
CompTox Dashboard (EPA)	DTXSID6023446 ;
ECHA InfoCard	100.150.427
Chemical and physical data
Formula	C17H25N
Molar mass	243.394 g·mol−1
3D model (JSmol)	Interactive image;
Melting point	46.5 °C (115.7 °F)
Boiling point	136 °C (277 °F)
	SMILES c1ccccc1C2(CCCCC2)N3CCCCC3;
	InChI InChI=1S/C17H25N/c1-4-10-16(11-5-1)17(12-6-2-7-13-17)18-14-8-3-9-15-18/h1,4-5,10-11H,2-3,6-9,12-15H2 ; Key:JTJMJGYZQZDUJJ-UHFFFAOYSA-N ;
Data page
	Phencyclidine (data page)
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Phencyclidine or phenylcyclohexyl piperidine (PCP), also known in its use as a street drug as angel dust among other names, is a dissociative anesthetic mainly used recreationally for its significant mind-altering effects. PCP may cause hallucinations, distorted perceptions of sounds, and psychotic behavior. As a recreational drug, it is typically smoked, but may be taken by mouth, snorted, or injected. It may also be mixed with cannabis or tobacco.

Adverse effects may include paranoia, addiction, and an increased risk of suicide, as well as seizures and coma in cases of overdose. Flashbacks may occur despite stopping usage. Chemically, PCP is a member of the arylcyclohexylamine class. PCP works primarily as an NMDA receptor antagonist.

PCP is most commonly used in the US. While usage peaked in the US in the 1970s, between 2005 and 2011, an increase in visits to emergency departments as a result of the drug occurred. As of 2022, in the US, about 0.7% of 12th-grade students reported using PCP in the prior year, while 1.7% of people in the US over age 25 reported using it at some point in their lives.