Progesterone receptor A

The progesterone receptor A (PR-A) is one of three known isoforms of the progesterone receptor (PR), the main biological target of the endogenous progestogen sex hormone progesterone. The other isoforms of the PR include the PR-B and PR-C.

PR-A is 164 residues shorter than PR-B in humans and anywhere from 128-165 residues shorter in other organisms. Each isoform binds its natural ligand, progesterone, but also demonstrates the ability to bind a number of other agonists including norethindrone, a synthetic progestin.

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