RAD21

RAD21
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4PJU, 4PJW, 4PK7
Identifiers
Aliases	RAD21, CDLS4, HR21, HMCD1, NXP1, SCC1, hHR21, RAD21 cohesin complex component, MGS
External IDs	OMIM: 606462; MGI: 108016; HomoloGene: 38161; GeneCards: RAD21; OMA:RAD21 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	116,874,776 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	51,855,143 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; superficial temporal artery; ; epithelium of nasopharynx; ; germinal epithelium; ; cerebellar vermis; ; pars reticulata; ; subthalamic nucleus; ; pars compacta; ; trabecular bone;
	Top expressed in
	Gonadal ridge; ; human fetus; ; left lung lobe; ; hand; ; tail of embryo; ; dermis; ; medial ganglionic eminence; ; migratory enteric neural crest cell; ; lobe of cerebellum; ; genital tubercle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription activator activity, RNA polymerase II-specific; protein binding; chromatin binding; protein-containing complex binding;
Cellular component	cytosol; membrane; chromosome; nucleoplasm; condensed nuclear chromosome; nuclear chromosome; chromatin; chromosome, centromeric region; nucleus; cohesin complex; nuclear matrix; meiotic cohesin complex; spindle pole; cytoplasm; cytoskeleton;
Biological process	reciprocal meiotic recombination; DNA recombination; chromosome segregation; regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; cellular response to DNA damage stimulus; cell division; double-strand break repair; cell cycle; protein localization to chromatin; DNA repair; positive regulation of transcription by RNA polymerase II; apoptotic process; sister chromatid cohesion; positive regulation of sister chromatid cohesion; negative regulation of G2/M transition of mitotic cell cycle; negative regulation of mitotic metaphase/anaphase transition; meiosis; multicellular organism development;
	Sources:Amigo / QuickGO
Orthologs
	5885
	19357
	ENSG00000164754
	ENSMUSG00000022314
	O60216
	Q61550
	NM_006265
	NM_009009
	NP_006256
	NP_033035
	Wikidata
View/Edit Human	View/Edit Mouse

Double-strand-break repair protein rad21 homolog is a protein that in humans is encoded by the RAD21 gene. RAD21 (also known as Mcd1, Scc1, KIAA0078, NXP1, HR21), an essential gene, encodes a DNA double-strand break (DSB) repair protein that is evolutionarily conserved in all eukaryotes from budding yeast to humans. RAD21 protein is a structural component of the highly conserved cohesin complex consisting of RAD21, SMC1A, SMC3, and SCC3 [ STAG1 (SA1) and STAG2 (SA2) in multicellular organisms] proteins, involved in sister chromatid cohesion.