SMC1A

SMC1A
Available structures
PDB	Ortholog search: Q68EN4 PDBe Q68EN4 RCSB
List of PDB id codes
	2WD5
Identifiers
Aliases	SMC1A, CDLS2, DXS423E, SB1.8, SMC1, SMC1L1, SMC1alpha, SMCB, structural maintenance of chromosomes 1A, EIEE85, DEE85
External IDs	OMIM: 300040; MGI: 1344345; HomoloGene: 4597; GeneCards: SMC1A; OMA:SMC1A - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	53,422,728 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	150,845,690 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; trabecular bone; ; embryo; ; tendon of biceps brachii; ; jejunal mucosa; ; germinal epithelium; ; ventricular zone; ; mucosa of sigmoid colon; ; tibia; ; Achilles tendon;
	Top expressed in
	genital tubercle; ; Rostral migratory stream; ; tail of embryo; ; neural layer of retina; ; fetal liver hematopoietic progenitor cell; ; ventricular zone; ; external carotid artery; ; internal carotid artery; ; dermis; ; maxillary prominence;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; mediator complex binding; chromatin binding; protein binding; protein heterodimerization activity; ATP binding; RNA binding; protein-containing complex binding;
Cellular component	meiotic cohesin complex; chromosome; nucleoplasm; condensed nuclear chromosome; chromosome, centromeric region; nucleus; kinetochore; cytosol; cohesin complex; nuclear matrix; mitotic spindle pole;
Biological process	chromosome organization; cellular response to DNA damage stimulus; stem cell population maintenance; cell division; negative regulation of DNA endoreduplication; mitotic sister chromatid cohesion; mitotic sister chromatid segregation; cell cycle; response to radiation; DNA repair; sister chromatid cohesion; response to DNA damage checkpoint signaling; meiosis; regulation of mitotic spindle assembly;
	Sources:Amigo / QuickGO
Orthologs
	8243
	24061
	ENSG00000072501
	ENSMUSG00000041133
	Q14683
	Q9CU62
	NM_006306; NM_001281463
	NM_019710
	NP_001268392; NP_006297; NP_006297.2
	NP_062684
	Wikidata
View/Edit Human	View/Edit Mouse

Structural maintenance of chromosomes protein 1A (SMC1A) is a protein that in humans is encoded by the SMC1A gene. SMC1A is a subunit of the cohesin complex which mediates sister chromatid cohesion, homologous recombination and DNA looping. In somatic cells, cohesin is formed of SMC1A, SMC3, RAD21 and either SA1 or SA2 whereas in meiosis, cohesin is formed of SMC3, SMC1B, REC8 and SA3.

SMC1A is a member of the SMC protein family. Members of this family are key regulators of DNA repair, chromosome condensation and chromosome segregation from bacteria to humans.