RAPGEF3

RAPGEF3
Identifiers
Aliases	RAPGEF3, CAMP-GEFI, EPAC, EPAC1, HSU79275, bcm910, Rap guanine nucleotide exchange factor 3
External IDs	OMIM: 606057; MGI: 2441741; HomoloGene: 21231; GeneCards: RAPGEF3; OMA:RAPGEF3 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	47,771,040 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	97,767,972 bp
RNA expression pattern
	Top expressed in
	right lobe of thyroid gland; ; apex of heart; ; right ovary; ; left lobe of thyroid gland; ; left ovary; ; tendon of biceps brachii; ; right uterine tube; ; sural nerve; ; canal of the cervix; ; ectocervix;
	Top expressed in
	aortic valve; ; motor neuron; ; ascending aorta; ; retinal pigment epithelium; ; ciliary body; ; right kidney; ; vestibular membrane of cochlear duct; ; iris; ; Rostral migratory stream; ; renal cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; protein domain specific binding; cAMP binding; protein binding; guanyl-nucleotide exchange factor activity;
Cellular component	filopodium; microvillus; cortical actin cytoskeleton; extracellular exosome; endomembrane system; lamellipodium; intracellular anatomical structure; membrane; plasma membrane;
Biological process	establishment of endothelial barrier; regulation of actin cytoskeleton reorganization; intracellular signal transduction; regulation of insulin secretion; small GTPase mediated signal transduction; Rap protein signal transduction; positive regulation of syncytium formation by plasma membrane fusion; regulation of histone H3-K9 acetylation; positive regulation of peptidyl-serine phosphorylation; positive regulation of angiogenesis; positive regulation of protein acetylation; positive regulation of protein export from nucleus; positive regulation of GTPase activity; angiogenesis; cell population proliferation; cAMP-mediated signaling; positive regulation of stress fiber assembly; signal transduction; cellular response to cAMP; negative regulation of syncytium formation by plasma membrane fusion;
	Sources:Amigo / QuickGO
Orthologs
	10411
	223864
	ENSG00000079337
	ENSMUSG00000022469
	O95398
	Q8VCC8
	NM_001098531; NM_001098532; NM_006105
	NM_001177810; NM_001177811; NM_144850; NM_001357630
	NP_001092001; NP_001092002; NP_006096
	NP_001171281; NP_001171282; NP_659099; NP_001344559
	Wikidata
View/Edit Human	View/Edit Mouse

Rap guanine nucleotide exchange factor 3 also known as exchange factor directly activated by cAMP 1 (EPAC1) or cAMP-regulated guanine nucleotide exchange factor I (cAMP-GEFI) is a protein that in humans is encoded by the RAPGEF3 gene.

As the name suggests, EPAC proteins (EPAC1 and EPAC2) are a family of intracellular sensors for cAMP, and function as nucleotide exchange factors for the Rap subfamily of RAS-like small GTPases.