REG1A

REG1A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1LIT, 1QDD
Identifiers
Aliases	REG1A, ICRF, P19, PSP, PSPS, PSPS1, PTP, REG, regenerating family member 1 alpha
External IDs	OMIM: 167770; MGI: 97895; HomoloGene: 68282; GeneCards: REG1A; OMA:REG1A - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	79,123,409 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; islet of Langerhans; ; beta cell; ; duodenum; ; mucosa of ileum; ; jejunal mucosa; ; pancreatic ductal cell; ; pylorus; ; gallbladder; ; cardia;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	carbohydrate binding; growth factor activity; transmembrane signaling receptor activity; signaling receptor binding; phosphatase binding; protein phosphatase binding; identical protein binding; protein homodimerization activity; peptidoglycan binding; oligosaccharide binding;
Cellular component	extracellular region; extracellular exosome; extracellular space; cytosol; growth cone; dendrite membrane; neuronal cell body membrane; protein-containing complex; zymogen granule; basal part of cell; perinuclear region of cytoplasm;
Biological process	positive regulation of cell population proliferation; regulation of signaling receptor activity; response to hypoxia; midgut development; negative regulation of cell population proliferation; positive regulation of gene expression; response to organic cyclic compound; response to nutrient levels; wound healing; response to peptide hormone; cell wall disruption in other organism; protein homooligomerization; protein homotetramerization; calcium ion homeostasis; antimicrobial humoral immune response mediated by antimicrobial peptide; liver regeneration; response to acetylsalicylate; positive regulation of dendrite extension; positive regulation of type B pancreatic cell proliferation; positive regulation of acinar cell proliferation; response to water-immersion restraint stress; pancreas regeneration; response to growth hormone-releasing hormone; response to gastrin; cellular response to chemokine; cellular response to gastrin; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	5967
	19692
	ENSG00000115386
	n/a
	P05451
	P43137
	NM_002909
	NM_009042
	NP_002900
	NP_033068
	Wikidata
View/Edit Human	View/Edit Mouse

Pancreatic Stone Protein (PSP), also known as Lithostathine-1-alpha islet cells regeneration factor (ICRF) or islet of Langerhans regenerating protein (REG) is a protein that in humans is encoded by the REG1A gene as a single polypeptide of 144 amino acids further cleaved by trypsin to produce a 133 amino acid protein that is O-linked glycosylated on threonine 27. This protein is a type I subclass member of the Regenerating protein family. The Reg protein family is a multi protein family grouped into four subclasses, types I, II, III and IV based on the primary structures of the proteins. Reg family members REG1B, REGL, PAP and this gene are tandemly clustered on chromosome 2p12 and may have arisen from the same ancestral gene by gene duplication. The PSP is mostly produced in Human by the acinar cells of the pancreas and is secreted in the duodenum by the same pathway that pancreatic exocrine enzymes. It has C-terminal C-type lectin domain whose binding partner is currently unknown.