Repulsive guidance molecule A

RGMA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4UHY
Identifiers
Aliases	RGMA, RGM, repulsive guidance molecule family member a, repulsive guidance molecule BMP co-receptor a
External IDs	OMIM: 607362; MGI: 2679262; HomoloGene: 10626; GeneCards: RGMA; OMA:RGMA - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	93,089,211 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	73,069,647 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; ventricular zone; ; tibialis anterior muscle; ; muscle of thigh; ; muscle layer of sigmoid colon; ; canal of the cervix; ; gastric mucosa; ; left uterine tube; ; Hypothalamus; ; apex of heart;
	Top expressed in
	ventricular zone; ; medial habenular nucleus; ; lip; ; interpeduncular nucleus; ; paraventricular nucleus of thalamus; ; layer of dentate gyrus; ; enteric plexus; ; molecular layer of neocortex; ; lumbar subsegment of spinal cord; ; superior frontal gyrus;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferrin receptor binding; protein binding; coreceptor activity;
Cellular component	anchored component of membrane; plasma membrane; endoplasmic reticulum; membrane;
Biological process	positive regulation of transcription by RNA polymerase II; BMP signaling pathway; negative regulation of axon regeneration; regulation of neuron projection development;
	Sources:Amigo / QuickGO
Orthologs
	56963
	244058
	ENSG00000182175
	ENSMUSG00000070509
	Q96B86
	Q6PCX7
NM_020211; NM_001166283; NM_001166286; NM_001166287; NM_001166288;
	NM_001166289
	NM_177740
NP_001159755; NP_001159758; NP_001159759; NP_001159760; NP_001159761;
	NP_064596
	NP_808408
	Wikidata
View/Edit Human	View/Edit Mouse

Repulsive guidance molecule A (RGMa) is a bone morphogenetic protein (BMP) co-receptor of the repulsive guidance molecule family. Together with BMPR1A and BMPR1B, as well as ACVR2A and BMPR2, it binds BMPs thereby activating the intracellular SMAD1/5/8 signalling pathway. In humans this protein is encoded by the RGMA gene.