RNASEH2B

RNASEH2B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3P56, 3P87, 3PUF
Identifiers
Aliases	RNASEH2B, AGS2, DLEU8, ribonuclease H2 subunit B
External IDs	OMIM: 610326; MGI: 1914403; HomoloGene: 41572; GeneCards: RNASEH2B; OMA:RNASEH2B - orthologs
Gene location (Human)
Chr.	Chromosome 13 (human)
End	51,024,120 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	62,610,441 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; ganglionic eminence; ; ventricular zone; ; granulocyte; ; body of pancreas; ; monocyte; ; olfactory zone of nasal mucosa; ; rectum; ; muscle layer of sigmoid colon; ; body of uterus;
	Top expressed in
	genital tubercle; ; ventricular zone; ; tail of embryo; ; superior cervical ganglion; ; medial ganglionic eminence; ; primitive streak; ; yolk sac; ; right kidney; ; embryo; ; endocardial cushion;
	More reference expression data
	n/a
Gene ontology
Molecular function	RNA-DNA hybrid ribonuclease activity;
Cellular component	ribonuclease H2 complex; nucleus; nucleoplasm;
Biological process	regulation of G2/M transition of mitotic cell cycle; RNA catabolic process; in utero embryonic development; RNA phosphodiester bond hydrolysis, endonucleolytic; ribonucleotide metabolic process; regulation of DNA damage checkpoint; negative regulation of gene expression; positive regulation of fibroblast proliferation;
	Sources:Amigo / QuickGO
Orthologs
	79621
	67153
	ENSG00000136104
	ENSMUSG00000021932
	Q5TBB1; Q8N451
	Q80ZV0
	NM_001142279; NM_024570
	NM_026001
	NP_001135751; NP_078846; NP_078846.2
	NP_080277
	Wikidata
View/Edit Human	View/Edit Mouse

Ribonuclease H2, subunit B is a protein in humans that is encoded by the RNASEH2B gene. RNase H2 is composed of a single catalytic subunit (A) and two non-catalytic subunits (B and C), and it degrades the RNA of RNA:DNA hybrids. The non-catalytic B subunit of RNase H2 is thought to play a role in DNA replication and repair.

Mutations in this gene are a cause of Aicardi-Goutieres syndrome type 2 (AGS2).