RNASEH2C

RNASEH2C
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3P56, 3PUF
Identifiers
Aliases	RNASEH2C, AGS3, AYP1, ribonuclease H2 subunit C
External IDs	OMIM: 610330; MGI: 1915459; HomoloGene: 32666; GeneCards: RNASEH2C; OMA:RNASEH2C - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	65,720,818 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	5,657,047 bp
RNA expression pattern
	Top expressed in
	pancreatic ductal cell; ; tendon of biceps brachii; ; apex of heart; ; right auricle of heart; ; left coronary artery; ; right hemisphere of cerebellum; ; thoracic aorta; ; ascending aorta; ; right adrenal gland; ; Descending thoracic aorta;
	Top expressed in
	internal carotid artery; ; saccule; ; otic placode; ; external carotid artery; ; otic vesicle; ; Paneth cell; ; granulocyte; ; tibiofemoral joint; ; fossa; ; condyle;
	More reference expression data
	n/a
Gene ontology
Molecular function	RNA-DNA hybrid ribonuclease activity;
Cellular component	nucleus; ribonuclease H2 complex;
Biological process	RNA catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	84153
	68209
	ENSG00000172922
	ENSMUSG00000024925
	Q8TDP1
	Q9CQ18
	NM_032193
	NM_026616
	NP_115569
	NP_080892
	Wikidata
View/Edit Human	View/Edit Mouse

Ribonuclease H2 subunit C is a protein that in humans is encoded by the RNASEH2C gene. RNase H2 is composed of a single catalytic subunit (A) and two non-catalytic subunits (B and C), and degrades the RNA of RNA:DNA hybrids.

Mutations in this gene are a cause of Aicardi-Goutieres syndrome type 3 (AGS3).