RNF7

RNF7
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2ECL
Identifiers
Aliases	RNF7, CKBBP1, ROC2, SAG, ring finger protein 7, rbx2
External IDs	OMIM: 603863; MGI: 1337096; HomoloGene: 84476; GeneCards: RNF7; OMA:RNF7 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	141,747,560 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	96,360,728 bp
RNA expression pattern
	Top expressed in
	left adrenal gland; ; left adrenal cortex; ; right adrenal gland; ; right adrenal cortex; ; right testis; ; muscle layer of sigmoid colon; ; left testis; ; anterior pituitary; ; body of pancreas; ; muscle of thigh;
	Top expressed in
	Epithelium of choroid plexus; ; ureter; ; morula; ; morula; ; iris; ; median eminence; ; gastrula; ; supraoptic nucleus; ; epithelium of lens; ; vestibular membrane of cochlear duct;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; zinc ion binding; copper ion binding; cullin family protein binding; metal ion binding; NEDD8 transferase activity; ubiquitin protein ligase activity;
Cellular component	nucleoplasm; nucleus; Cul5-RING ubiquitin ligase complex; cytoplasm; cytosol; Cul2-RING ubiquitin ligase complex; Cul3-RING ubiquitin ligase complex; Cul7-RING ubiquitin ligase complex; nuclear SCF ubiquitin ligase complex; Cul4-RING E3 ubiquitin ligase complex; cullin-RING ubiquitin ligase complex;
Biological process	response to redox state; protein ubiquitination; protein neddylation; post-translational protein modification; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; ubiquitin-dependent protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	9616
	19823
	ENSG00000114125
	ENSMUSG00000051234
	Q9UBF6
	Q9WTZ1
	NM_001201370; NM_014245; NM_183063; NM_183237
	NM_011279; NM_001311135
	NP_001188299; NP_055060; NP_899060
	NP_001298064; NP_035409
	Wikidata
View/Edit Human	View/Edit Mouse

RING-box protein 2 is a protein that in humans is encoded by the RNF7 gene.

The protein encoded by this gene is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, casein kinase II (CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27^Kip1(CDKN1B). Alternatively spliced transcript variants encoding distinct isoforms have been reported.