60S ribosomal protein L23

RPL23
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3J7R, 4V5Z, 4V6X, 4UJD, 3J7P, 4D67, 3J92, 4D5Y, 5AJ0, 3J7Q, 4UG0, 4UJE, 3J7O, 4UJC
Identifiers
Aliases	RPL23, L23, rpL17, ribosomal protein L23
External IDs	OMIM: 603662; MGI: 1929455; HomoloGene: 68103; GeneCards: RPL23; OMA:RPL23 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	38,853,764 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	97,673,263 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; left ovary; ; right ovary; ; ventricular zone; ; right uterine tube; ; monocyte; ; canal of the cervix; ; body of uterus; ; right lung; ; left adrenal cortex;
	Top expressed in
	yolk sac; ; embryo; ; embryo; ; ventricular zone; ; lip; ; morula; ; blastocyst; ; neural layer of retina; ; muscle of thigh; ; dentate gyrus of hippocampal formation granule cell;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	structural constituent of ribosome; large ribosomal subunit rRNA binding; protein binding; RNA binding; transcription coactivator binding; ubiquitin protein ligase binding; ubiquitin ligase inhibitor activity;
Cellular component	cytosol; ribosome; membrane; focal adhesion; extracellular exosome; cytosolic large ribosomal subunit; extracellular matrix; nucleoplasm; cytoplasm; nucleolus; postsynaptic density; protein-containing complex;
Biological process	ribosomal protein import into nucleus; viral transcription; SRP-dependent cotranslational protein targeting to membrane; translational initiation; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; protein biosynthesis; rRNA processing; negative regulation of transcription by RNA polymerase II; positive regulation of cell population proliferation; positive regulation of gene expression; protein-DNA complex disassembly; positive regulation of transcription by RNA polymerase II; protein stabilization; cellular response to actinomycin D; positive regulation of signal transduction by p53 class mediator; negative regulation of ubiquitin protein ligase activity; negative regulation of ubiquitin-dependent protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	9349
	65019
	ENSG00000125691
	ENSMUSG00000071415
	P62829
	P62830
	NM_000978
	NM_022891
	NP_000969
	NP_075029
	Wikidata
View/Edit Human	View/Edit Mouse

Large ribosomal subunit protein uL14 is a protein that in humans is encoded by the RPL23 gene.

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the universal ribosomal protein uL14 family. It is located in the cytoplasm. This gene has been referred to as RPL17 because the encoded protein shares amino acid identity with ribosomal protein L17 from Saccharomyces cerevisiae; however, its official symbol is RPL23. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.