R-spondin 1

RSPO1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4BSO, 4BSP, 4BSR, 4BSS, 4BST, 4BSU, 4CDK, 4KNG, 4KT1, 4LI2, 4QXF
Identifiers
Aliases	RSPO1, CRISTIN3, RSPO, R-spondin 1
External IDs	OMIM: 609595; MGI: 2183426; HomoloGene: 52148; GeneCards: RSPO1; OMA:RSPO1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	37,634,892 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	124,902,892 bp
RNA expression pattern
	Top expressed in
	canal of the cervix; ; body of uterus; ; germinal epithelium; ; ectocervix; ; right uterine tube; ; left uterine tube; ; myometrium; ; smooth muscle tissue; ; vagina; ; gastric mucosa;
	Top expressed in
	superior surface of tongue; ; lens; ; gallbladder; ; epithelium of lens; ; efferent ductule; ; adventitia of seminal vesicle; ; papillary dermis; ; Stroma of ovary; ; muscle layer of seminal vesicle; ; lumbar spinal ganglion;
	More reference expression data
	n/a
Gene ontology
Molecular function	heparin binding; signaling receptor binding; protein binding; G protein-coupled receptor binding; frizzled binding;
Cellular component	extracellular region; nucleus; extracellular space;
Biological process	positive regulation of canonical Wnt signaling pathway; positive regulation of Wnt signaling pathway; regulation of receptor internalization; positive regulation of protein phosphorylation; Wnt signaling pathway; response to stimulus;
	Sources:Amigo / QuickGO
Orthologs
	284654
	192199
	ENSG00000169218
	ENSMUSG00000028871
	Q2MKA7
	Q9Z132
	NM_001038633; NM_001242908; NM_001242909; NM_001242910; NM_173640
	NM_138683
	NP_001033722; NP_001229837; NP_001229838; NP_001229839
	NP_619624
	Wikidata
View/Edit Human	View/Edit Mouse

R-spondin-1 is a secreted protein that in humans is encoded by the RSPO1 gene, found on chromosome 1. In humans, it interacts with WNT4 in the process of female sex development. Loss of function can cause female to male sex reversal. Furthermore, it promotes canonical WNT/β catenin signaling.