RTI-7470-44

RTI-7470-44
Clinical data
Drug class	Trace amine-associated receptor 1 (TAAR1) antagonist
Identifiers
	IUPAC name 2-[6-(4-chlorophenyl)-3-cyano-4-(trifluoromethyl)pyridin-2-yl]sulfanyl-N-pyrimidin-2-ylacetamide;
CAS Number	825658-63-7;
PubChem CID	2225078;
ChemSpider	1663640;
Chemical and physical data
Formula	C19H11ClF3N5OS
Molar mass	449.84 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1=CN=C(N=C1)NC(=O)CSC2=C(C(=CC(=N2)C3=CC=C(C=C3)Cl)C(F)(F)F)C#N;
	InChI InChI=1S/C19H11ClF3N5OS/c20-12-4-2-11(3-5-12)15-8-14(19(21,22)23)13(9-24)17(27-15)30-10-16(29)28-18-25-6-1-7-26-18/h1-8H,10H2,(H,25,26,28,29); Key:WHNQNKYKDSLDKM-UHFFFAOYSA-N;

RTI-7470-44 is a potent and selective antagonist of the human trace amine-associated receptor 1 (TAAR1) which is used in scientific research. It was discovered in 2022 and is the first potent antagonist of the human TAAR1 to be identified, following the potent mouse TAAR1 inverse agonist EPPTB in 2009.