Reticulon 4 receptor

RTN4R
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1OZN, 1P8T
Identifiers
Aliases	RTN4R, NGR, NOGOR, Reticulon 4 receptor
External IDs	OMIM: 605566; MGI: 2136886; HomoloGene: 11299; GeneCards: RTN4R; OMA:RTN4R - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	20,283,246 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	17,970,272 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; testicle; ; right frontal lobe; ; Brodmann area 9; ; prefrontal cortex; ; cingulate gyrus; ; anterior cingulate cortex; ; cerebellar vermis; ; Amygdala; ; primary visual cortex;
	Top expressed in
	primary visual cortex; ; hippocampus proper; ; Cortex of frontal lobe; ; superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; Anterior olfactory nucleus; ; layer of neocortex; ; cerebellar cortex; ; secondary oocyte; ; multiform layer of neocortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	neuregulin receptor activity; protein kinase inhibitor activity; protein binding; heparin binding; chondroitin sulfate binding; ganglioside GM1 binding; ganglioside GT1b binding; lipid binding; signaling receptor activity; protein-containing complex binding;
Cellular component	cytoplasm; membrane; growth cone; plasma membrane; axonal growth cone; integral component of plasma membrane; soma; endoplasmic reticulum; anchored component of membrane; neuron projection; extracellular exosome; cell surface; anchored component of external side of plasma membrane; dendritic shaft; membrane raft; axon; dendrite; cell projection; perikaryon; presynapse; glutamatergic synapse;
Biological process	negative regulation of protein kinase activity; cytokine-mediated signaling pathway; neuronal signal transduction; positive regulation of GTPase activity; negative regulation of axonogenesis; negative regulation of axon extension; negative regulation of receptor signaling pathway via JAK-STAT; negative regulation of neuron projection development; negative regulation of axon regeneration; cell surface receptor signaling pathway; axonogenesis; corpus callosum development; positive regulation of Rho protein signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	65078
	65079
	ENSG00000040608
	ENSMUSG00000043811
	Q9BZR6
	Q99PI8
	NM_023004
	NM_022982
	NP_075380
	NP_075358
	Wikidata
View/Edit Human	View/Edit Mouse

Reticulon 4 receptor (RTN4R) also known as Nogo-66 Receptor (NgR) or Nogo receptor 1 is a protein which in humans is encoded by the RTN4R gene. This gene encodes the receptor for reticulon 4, oligodendrocytemyelin glycoprotein and myelin-associated glycoprotein. This receptor mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system.