RuvB-like 1

RUVBL1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2C9O, 2XSZ
Identifiers
Aliases	RUVBL1, ECP54, INO80H, NMP238, PONTIN, Pontin52, RVB1, TIH1, TIP49, TIP49A, ECP-54, NMP 238, RuvB like AAA ATPase 1
External IDs	OMIM: 603449; MGI: 1928760; HomoloGene: 37839; GeneCards: RUVBL1; OMA:RUVBL1 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	128,153,914 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	88,474,554 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; ventricular zone; ; gonad; ; olfactory zone of nasal mucosa; ; ganglionic eminence; ; islet of Langerhans; ; stromal cell of endometrium; ; right testis; ; left testis; ; placenta;
	Top expressed in
	epiblast; ; tail of embryo; ; embryo; ; embryo; ; lens; ; ventricular zone; ; neural tube; ; ganglionic eminence; ; yolk sac; ; blastocyst;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; 5'-3' DNA helicase activity; helicase activity; DNA helicase activity; ATPase activity; protein binding; hydrolase activity; ATP binding; cadherin binding; TFIID-class transcription factor complex binding; ADP binding; ATPase binding;
Cellular component	membrane; nuclear matrix; NuA4 histone acetyltransferase complex; nucleoplasm; microtubule organizing center; MLL1 complex; extracellular exosome; cytoskeleton; nucleus; Swr1 complex; R2TP complex; cytoplasm; cytosol; Ino80 complex;
Biological process	DNA recombination; regulation of transcription, DNA-templated; positive regulation of protein targeting to mitochondrion; histone H2A acetylation; regulation of transcription by RNA polymerase II; CENP-A containing chromatin assembly; transcription, DNA-templated; cellular response to DNA damage stimulus; cell division; regulation of autophagy of mitochondrion; spermatogenesis; positive regulation of telomerase RNA localization to Cajal body; histone H4 acetylation; cell cycle; regulation of growth; beta-catenin-TCF complex assembly; DNA duplex unwinding; protein deubiquitination; DNA repair; box C/D snoRNP assembly; chromatin remodeling;
	Sources:Amigo / QuickGO
Orthologs
	8607
	56505
	ENSG00000175792; ENSG00000284901
	ENSMUSG00000030079
	Q9Y265
	P60122
	NM_003707; NM_001319084; NM_001319086
	NM_019685
	NP_001306013; NP_001306015; NP_003698
	NP_062659
	Wikidata
View/Edit Human	View/Edit Mouse

RuvB-like 1 (E. coli), also known as RUVBL1 and TIP49, is a human gene. RUVBL1 can form a hexamer. The hexamer can form a dodecamer with RUVBL2 protein. Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity.