Relaxin
| Relaxin 1 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | RLN1 | ||||||
| Alt. symbols | H1 | ||||||
| NCBI gene | 6013 | ||||||
| HGNC | 10026 | ||||||
| OMIM | 179730 | ||||||
| RefSeq | NM_006911 | ||||||
| UniProt | P04808 | ||||||
| Other data | |||||||
| Locus | Chr. 9 qter-q12 | ||||||
| |||||||
| Relaxin 2 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | RLN2 | ||||||
| Alt. symbols | H2, RLXH2, bA12D24.1.1, bA12D24.1.2 | ||||||
| NCBI gene | 6019 | ||||||
| HGNC | 10027 | ||||||
| OMIM | 179740 | ||||||
| PDB | 6RLX | ||||||
| RefSeq | NM_134441 | ||||||
| UniProt | P04090 | ||||||
| Other data | |||||||
| Locus | Chr. 9 qter-q12 | ||||||
| |||||||
| Relaxin 3 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | RLN3 | ||||||
| Alt. symbols | ZINS4, RXN3, H3 | ||||||
| NCBI gene | 117579 | ||||||
| HGNC | 17135 | ||||||
| OMIM | 606855 | ||||||
| RefSeq | NM_080864 | ||||||
| UniProt | Q8WXF3 | ||||||
| Other data | |||||||
| Locus | Chr. 19 p13.3 | ||||||
| |||||||
Relaxin is a protein hormone of about 6000 Da, first described in 1926 by Frederick Hisaw.
The relaxin family peptide hormones belong to the insulin superfamily and consists of seven peptides of high structural but low sequence similarity; relaxin-1 (RLN1), 2 (RLN2) and 3 (RLN3), and the insulin-like (INSL) peptides, INSL3, INSL4, INSL5 and INSL6. The functions of relaxin-3, INSL4, INSL5, and INSL6 remain uncharacterised.