Relaxin receptor

relaxin/insulin-like family peptide receptor 1
Identifiers
SymbolRXFP1
Alt. symbolsLGR7
NCBI gene59350
HGNC19718
OMIM606654
RefSeqNM_021634
UniProtQ9HBX9
Other data
LocusChr. 4 q31.3
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StructuresSwiss-model
DomainsInterPro
relaxin/insulin-like family peptide receptor 2
Identifiers
SymbolRXFP2
Alt. symbolsLGR8, GREAT, GPR106, INSL3R
NCBI gene122042
HGNC17318
OMIM606655
RefSeqNM_130806
UniProtQ8WXD0
Other data
LocusChr. 13 q12.3
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DomainsInterPro
relaxin/insulin-like family peptide receptor 3
Identifiers
SymbolRXFP3
Alt. symbolsRLN3R1, SALPR, GPCR135
NCBI gene51289
HGNC24883
OMIM609445
RefSeqNM_016568
UniProtQ9NSD7
Other data
LocusChr. 5 p15.1-p14
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relaxin/insulin-like family peptide receptor 4
Identifiers
SymbolRXFP4
Alt. symbolsGPR100, GPCR142, RLN3R2
NCBI gene339403
HGNC14666
OMIM609043
RefSeqNM_181885
UniProtQ8TDU9
Other data
LocusChr. 1 q22
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StructuresSwiss-model
DomainsInterPro

The relaxin receptors are a subclass of four closely related G protein-coupled receptors (GPCR) that bind relaxin peptide hormones.

Below is list of human relaxin receptors, their endogenous peptide hormones, and what downstream enzymes are activated or inhibited by the receptor.

receptor/gene ligands activates inhibits
RXFP1 relaxin 1, relaxin 2, relaxin 3 adenylate cyclase, protein kinase A, protein kinase C,

phosphatidylinositol 3-kinase, extracellular signal-regulated kinases (Erk1/2)
RXFP2 relaxin 1, relaxin 2, insulin-like 3 adenylate cyclase
RXFP3 relaxin 3 Erk1/2 signaling adenylate cyclase
RXFP4 relaxin 3, insulin-like 3 adenylate cyclase
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