SARM1

SARM1
Identifiers
Aliases	SARM1, MyD88-5, SAMD2, SARM, sterile alpha and TIR motif containing 1, hHsTIR
External IDs	OMIM: 607732; MGI: 2136419; HomoloGene: 9015; GeneCards: SARM1; OMA:SARM1 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	28,404,049 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	78,388,580 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; islet of Langerhans; ; ganglionic eminence; ; ventricular zone; ; anterior pituitary; ; granulocyte; ; right uterine tube; ; stromal cell of endometrium; ; right adrenal gland; ; body of uterus;
	Top expressed in
	superior cervical ganglion; ; neural layer of retina; ; stellate ganglion; ; dentate gyrus of hippocampal formation granule cell; ; spinal ganglia; ; thoracic ganglia; ; neural tube; ; ganglionic eminence; ; visual cortex; ; primary visual cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; signaling adaptor activity;
Cellular component	cytoplasm; cytosol; cell projection; microtubule cytoskeleton; synapse; extrinsic component of mitochondrial outer membrane; axon; cell junction; mitochondrion; microtubule; dendrite;
Biological process	regulation of apoptotic process; cell differentiation; immune system process; response to glucose; nervous system development; regulation of dendrite morphogenesis; negative regulation of MyD88-independent toll-like receptor signaling pathway; innate immune response; signal transduction; regulation of neuron death; positive regulation of signal transduction; response to axon injury;
	Sources:Amigo / QuickGO
Orthologs
	23098
	237868
	ENSG00000004139
	ENSMUSG00000050132
	Q6SZW1; Q0D2N8
	Q6PDS3
	NM_015077
	NM_001168521; NM_172795
	NP_055892; NP_055892.2
	NP_001161993; NP_766383
	Wikidata
View/Edit Human	View/Edit Mouse

Sterile alpha and TIR motif containing 1 Is an enzyme that in humans is encoded by the SARM1 gene. It is the most evolutionarily conserved member of the Toll/Interleukin receptor-1 (TIR) family. SARM1's TIR domain has intrinsic NADase enzymatic activity that is highly conserved from archaea, plants, nematode worms, fruit flies, and humans. In mammals, SARM1 is highly expressed in neurons, where it resides in both cell bodies and axons, and can be associated with mitochondria.