SAV1

SAV1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DWV, 2YSB
Identifiers
Aliases	SAV1, SAV, WW45, WWP4, salvador family WW domain containing protein 1
External IDs	OMIM: 607203; MGI: 1927144; HomoloGene: 32517; GeneCards: SAV1; OMA:SAV1 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	50,668,306 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	70,033,776 bp
RNA expression pattern
	Top expressed in
	oocyte; ; mucosa of paranasal sinus; ; secondary oocyte; ; nipple; ; lactiferous duct; ; olfactory zone of nasal mucosa; ; Achilles tendon; ; urethra; ; body of pancreas; ; superficial temporal artery;
	Top expressed in
	gastrula; ; spermatocyte; ; intercostal muscle; ; decidua; ; interventricular septum; ; calvaria; ; arm; ; upper arm; ; triceps brachii muscle; ; temporal muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; molecular adaptor activity; identical protein binding;
Cellular component	cytoplasm; nucleus; cytosol; intracellular anatomical structure;
Biological process	hair follicle development; ventricular septum morphogenesis; lung epithelial cell differentiation; protein stabilization; positive regulation of DNA-binding transcription factor activity; regulation of stem cell population maintenance; negative regulation of cardiac muscle cell proliferation; regulation of organ growth; positive regulation of fat cell differentiation; hippo signaling; intestinal epithelial cell differentiation; signal transduction; keratinocyte differentiation; negative regulation of epithelial cell proliferation; positive regulation of apoptotic process; apoptotic process; regulation of cell population proliferation;
	Sources:Amigo / QuickGO
Orthologs
	60485
	64010
	ENSG00000151748
	ENSMUSG00000021067
	Q9H4B6
	Q8VEB2
	NM_021818
	NM_022028
	NP_068590
	NP_071311
	Wikidata
View/Edit Human	View/Edit Mouse

Protein salvador homolog 1 is a protein that in humans is encoded by the SAV1 gene.

WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a coiled-coil region. It is ubiquitously expressed in adult tissues. The encoded protein is 94% identical to the mouse protein at the amino acid level.